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Effects of protein binding on the biodistribution of PEGylated PLGA nanoparticles post oral administration
(Elsevier B.V., 2012-03-15)
The surface of nanoparticles is often functionalised with polymeric surfactants, in order to increase systemic circulation time. This has been investigated mainly for intravenously administered nanoparticles. This study ...
Oral lipid-based nanoformulation of tafenoquine enhanced bioavailability and blood stage antimalarial efficacy and led to a reduction in human red blood cell loss in mice
(Dovepress, 2015-02-20)
: Tafenoquine (TQ), a new synthetic analog of primaquine, has relatively poor
bioavailability and associated toxicity in glucose-6-phosphate dehydrogenase (G6PD)-deficient
individuals. A microemulsion formulation of TQ ...
Antimicrobial packaging based on starch, poly(3-hydroxybutyrate) and poly(lactic-co-glycolide) materials and application challenges
(Elsevier Ltd., 2018-04)
Background
In recent years, food packaging has focused on two scientific pillars; adopting the biodegradable packaging materials and development of antimicrobial packaging for extended shelf life, quality and safety of ...
Standardization of natural mycolic acid antigen composition and production for use in biomarker antibody detection to diagnose active tuberculosis
(Elsevier B.V., 2016-08)
Mycobacterium tuberculosis, the causative agent of tuberculosis, is characterized by the abundance of species specific, antigenic cell wall lipids called mycolic acids. These wax-like molecules all share an identical, ...
Poly (D,L-lactide-co-glycolide) nanoparticles: Uptake by epithelial cells and cytotoxicity
(eXPRESS Polymer Letters, 2014)
Nanoparticles as drug delivery systems offer benefits such as protection of the encapsulated drug against degradation, site-specific targeting and prolonged blood circulation times. The aim of this study was to investigate ...
Design and formulation of nano-sized spray dried efavirenz-part I: influence of formulation parameters
(Springer Nature Switzerland AG., 2012-10-25)
Efavirenz (EFV) is one of the first-line antiretroviral drugs recommended by the World Health Organisation for treating HIV. It is a hydrophobic drug that suffers from low aqueous solubility (4 μg/mL), which leads to a ...
Optimized Preparation of Silver Nanoparticles from Polyethylene Glycol and Formaldehyde
(International Research Journal of Pure & Applied Chemistry, 2016-12-19)
The purpose of this work was to study the effect of various process and formulation parameters on
size and shapes of silver nanoparticles (AgNPs) based on surface plasmon resonance (SPR).
AgNPs were prepared by chemical ...
Preparation of rifampicin/lactose microparticle composites by a supercritical antisolvent-drug excipient mixing technique for inhalation delivery
(Elsevier, 2013-02)
Rifampicin (RIF) is precipitated in the presence of inhalable lactose particles using a supercritical antisolvent-drug excipient mixing (SAS-DEM) technique to create RIF/lactose microparticle composites intended to improve ...
Human food safety and environmental hazards associated with the use of methyltestosterone and other steroids in production of all-male tilapia
(Springer, 2015-04)
In recent years, all-male cultures of Nile tilapia (Oreochromis niloticus) have been the most preferred mode of production in aquaculture industry. All-male individuals achieve higher somatic growth rate and shut high ...
Preparation of rifampicin/poly(d,l-lactice) nanoparticles for sustained release by supercritical assisted atomization technique
(Elsevier, 2014-11)
In this work supercritical assisted atomization (SAA) process was used for the co-precipitation of poly(d,l-lactide) (PDLLA) and rifampicin (RIF) as nanoparticles for sustained release applications. The effect of the ...