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    Effects of protein binding on the biodistribution of PEGylated PLGA nanoparticles post oral administration 

    Semete, Boitumelo; Booysen, Laetitia; Kalombo, Lonji; Ramalapa, Bathabile; Hayeshi, Rose; Swai, Hulda (Elsevier B.V., 2012-03-15)
    The surface of nanoparticles is often functionalised with polymeric surfactants, in order to increase systemic circulation time. This has been investigated mainly for intravenously administered nanoparticles. This study ...
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    Oral lipid-based nanoformulation of tafenoquine enhanced bioavailability and blood stage antimalarial efficacy and led to a reduction in human red blood cell loss in mice 

    Melariri, Paula; Kalombo, Lonji; Nkuna, Patric; Dube, Admire; Hayeshi, Rose; Ogutu, Benhards; Gibhard, Liezl; deKock, Carmen; Smith, Peter; Wiesner, Lubbe; Swai, Hulda (Dovepress, 2015-02-20)
    : Tafenoquine (TQ), a new synthetic analog of primaquine, has relatively poor bioavailability and associated toxicity in glucose-6-phosphate dehydrogenase (G6PD)-deficient individuals. A microemulsion formulation of TQ ...
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    Spray-Dried, Nanoencapsulated, Multi-Drug Anti-Tuberculosis Therapy Aimed at OnceWeekly Administration for the Duration of Treatment 

    Kalombo, Lonji; Lemmer, Yolandy; Semete-Makokotlela, Boitumelo; Ramalapa, Bathabile; Nkuna, Patric; Booysen, Laetitia; Naidoo, Saloshnee; Hayeshi, Rose; Verschoor, Jan; Swai, Hulda (MDPI, 2019-08-15)
    Aiming to improve the treatment outcomes of current daily tuberculosis (TB) chemotherapy over several months, we investigated whether nanoencapsulation of existing drugs would allow decreasing the treatment frequency to ...
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    State of the art and future directions in nanomedicine for tuberculosis. 

    Dube, Admire; Lemmer, Yolandy; Hayeshi, Rose; Balogun, Mohammed; Labuschagne, Philip; Swai, Hulda; Kalombo, Lonji (Expert Opinion on Drug Delivery, 2013-12-01)
    Introduction: Tuberculosis (TB) ranks the second leading cause of death from an infectious disease worldwide. However, treatment of TB is affected by poor patient compliance due to the requirement for daily drug administration, ...
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    Nanomedicine: Past, present and future - A global perspective. 

    Chang, Esther; Harford, Joe; Eaton, Michael; Boisseau, Patrick; Dube, Admire; Hayeshi, Rose; Swai, Hulda; Lee, Dong (Elsevier Inc, 2015-12-18)
    Nanomedicine is an emerging and rapidly evolving field and includes the use of nanoparticles for diagnosis and therapy of a variety of diseases, as well as in regenerative medicine. In this mini-review, leaders in the field ...
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    Curdlan-Conjugated PLGA Nanoparticles Possess Macrophage Stimulant Activity and Drug Delivery Capabilities 

    Tukulula, Matshawandile; Hayeshi, Rose; Fonteh, Pascaline; Meyer, Debra; Ndamase, Abongile; Madziva, Michael T.; Khumalo, Vincent; Lubuschagne, Philip; Naicker, Brendon; Swai, Hulda; Dube, Admire (Springer, 2015-03-28)
    Purpose There is significant interest in the application of nanoparticles to deliver immunostimulatory signals to cells.We hypothesized that curdlan (immune stimulating polymer) could be conjugated to PLGA and nanoparticles ...

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    Hayeshi, Rose (6)
    Swai, Hulda (6)
    Dube, Admire (4)Kalombo, Lonji (4)Booysen, Laetitia (2)Lemmer, Yolandy (2)Nkuna, Patric (2)Ramalapa, Bathabile (2)Balogun, Mohammed (1)Boisseau, Patrick (1)... View MoreSubjectBiodistribution (1)Diagnostics (1)dose frequency (1)Drug delivery (1)Funding (1)G6PD deficiency (1)Imaging (1)immunostimulantnanoparticles (1)In vivo efficacy (1)Innovation (1)... View MoreDate Issued2015 (3)2012 (1)2013 (1)2019 (1)Has File(s)Yes (6)

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