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Now showing items 31-40 of 53
Development, characterization and antimalarial efficacy of dihydroartemisinin loaded solid lipid nanoparticles.
(Elsevier, 2016-04-01)
Effective use of dihydroartemisinin (DHA) is limited by poor water-solubility, poor pharmacokinetic profile and unsatisfactory clinical outcome especially in monotherapy. To reduce such limitations, we reformulated DHA ...
Enhanced oral bioavailability of the antiretroviral efavirenz encapsulated in poly(epsilon-caprolactone) nanoparticles by a spray-drying method.
(NANOMEDICINE, 2014-10-17)
Aim: To encapsulate efavirenz (EFV) within poly(epsilon-caprolactone) (PCL) nanoparticles (NPs) and compare the oral pharmacokinetics with that of EFV-loaded micelles and pure EFV NPs. Materials & methods: EFV-loaded PCL ...
State of the art and future directions in nanomedicine for tuberculosis.
(Expert Opinion on Drug Delivery, 2013-12-01)
Introduction: Tuberculosis (TB) ranks the second leading cause of death from an infectious disease worldwide. However, treatment of TB is affected by poor patient compliance due to the requirement for daily drug administration, ...
Modifications of the hydrophilicity of heterocyclic methacrylate copolymers for protein release
(Elsevier, 1995-12)
A series of copolymers comprising ethyl methacrylate (EM) and tetrahydrofurfuryl methacrylate (THFMA) gelled with either THFMA monomer or hydroxyethyl methacrylate (HEMA) monomer have been developed. In this paper, we ...
The water uptake of poly(tetrahydrofurfuryl methacrylate)
(Elsevier, 1999-03)
Poly(tetrahydrofurfuryl methacrylate) possesses some unique characteristics with respect to its biocompatibility and behaviour in water. The water uptake is high (>70%) and very slow (over 3 yr), but the material remains ...
Solvent effects on molecular encapsulation of Toussantine-A by chitosan nanoparticle: A metadynamics study
(Elsevier, 2019-10-15)
We report a metadynamics study of toussantine-A with chitosan nanoparticle in dimethyl sulfoxide and water in order to assess the solvent related effects on free energy and interaction stability between the two compounds. ...
Potential of treating tuberculosis with a polymeric nano-drug delivery system
(Elsevier, 2008-12-18)
An effective therapeutic regimen is available for the treatment of tuberculosis (TB), however in developing countries; patient non-compliance due to high dose frequency and the lengthy duration of treatment, presents a ...
Antimalarial potential and phytochemical composition of fractions of Lippia kituiensis Vatke (Verbenaceae) growing in Northern Tanzania
(Journal of Medicinal Plants Research, 2020-08-31)
Despite past decades of steady advances in the fight against Malaria, statistics show that the disease is still a threat to human health. Previous successes in the development of antimalarial drugs from medicinal plants ...
In vivo/in vitro pharmacokinetic and pharmacodynamic study of spray-dried poly-(dl-lactic-co-glycolic) acid nanoparticles encapsulating rifampicin and isoniazid.
(Elsevier B.V., 2013-02-28)
Poly-(dl-lactic-co-glycolic) acid (PLGA) nanoparticles were prepared by a double emulsion solvent evaporation spray-drying technique and coated with polyethylene glycol (PEG 1% v/v). The PLGA nanoparticles had a small size ...
Preparation of rifampicin/lactose microparticle composites by a supercritical antisolvent-drug excipient mixing technique for inhalation delivery
(Elsevier, 2013-02)
Rifampicin (RIF) is precipitated in the presence of inhalable lactose particles using a supercritical antisolvent-drug excipient mixing (SAS-DEM) technique to create RIF/lactose microparticle composites intended to improve ...