Search
Now showing items 11-20 of 53
The water uptake of poly(tetrahydrofurfuryl methacrylate)
(Elsevier, 1999-03)
Poly(tetrahydrofurfuryl methacrylate) possesses some unique characteristics with respect to its biocompatibility and behaviour in water. The water uptake is high (>70%) and very slow (over 3 yr), but the material remains ...
Solvent effects on molecular encapsulation of Toussantine-A by chitosan nanoparticle: A metadynamics study
(Elsevier, 2019-10-15)
We report a metadynamics study of toussantine-A with chitosan nanoparticle in dimethyl sulfoxide and water in order to assess the solvent related effects on free energy and interaction stability between the two compounds. ...
Antimalarial potential and phytochemical composition of fractions of Lippia kituiensis Vatke (Verbenaceae) growing in Northern Tanzania
(Journal of Medicinal Plants Research, 2020-08-31)
Despite past decades of steady advances in the fight against Malaria, statistics show that the disease is still a threat to human health. Previous successes in the development of antimalarial drugs from medicinal plants ...
Antimicrobial dependence of silver nanoparticles on surface plasmon resonance bands against Escherichia coli
(Dove Press Journal, 2016-12-16)
This study presents a simple and trouble-free method for determining the antimicrobial
properties of silver nanoparticles (AgNPs) based on the surface plasmon resonance
(SPR) bands. AgNPs were prepared by chemical reduction ...
Antimalarial activity of Cucumis metuliferus and Lippia kituiensis against Plasmodium berghei infection in mice
(Dovepress, 2018)
Background: The search for new antimalarial drugs has become progressively urgent due to
plasmodial resistance to most of the commercially available antimalarial drugs. As part of this
effort, the study evaluated the ...
Curdlan-Conjugated PLGA Nanoparticles Possess Macrophage Stimulant Activity and Drug Delivery Capabilities
(Springer, 2015-03-28)
Purpose There is significant interest in the application of nanoparticles
to deliver immunostimulatory signals to cells.We hypothesized
that curdlan (immune stimulating polymer) could be conjugated
to PLGA and nanoparticles ...
Comparative in vitro transportation of pentamidine across the blood-brain barrier using polycaprolactone nanoparticles and phosphatidylcholine liposomes
(Taylor & Francis Group., 2019-04-22)
Nanoparticles (NPs) have gained importance in addressing drug delivery challenges across biological
barriers. Here, we reformulated pentamidine, a drug used to treat Human African Trypanosomiasis
(HAT) in polymer based ...
A polymeric system for the intra-oral delivery of an anti-fungal agent
(Elsevier Science Ltd., 2001)
Oral candidal infections are often persistent and intractable and thus the aim of this study was to develop a polymeric sustained
release device to improve the topical treatment of these infections. A self curing system ...
Polyamidoamine Dendrimers for Enhanced Solubility of Small Molecules and Other Desirable Properties for Site Specific Delivery: Insights from Experimental and Computational Studies
(MDPI, 2018-06-12)
Clinical applications of many small molecules are limited due to poor solubility and lack
of controlled release besides lack of other desirable properties. Experimental and computational
studies have reported on the ...
Solvent effects on host-guest residence time and kinetics: further insights from metadynamics simulation of Toussaintine-A unbiding from chitosan nanoparticle
(Springer Nature Switzerland AG., 2021-04-14)
Solvents play an important role in host-guest intermolecular interactions. The kinetics and residence time of Toussaintine-A (TouA) unbinding from chitosan was investigated by means of well-tempered metadynamics and ...