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    Effects of protein binding on the biodistribution of PEGylated PLGA nanoparticles post oral administration 

    Semete, Boitumelo; Booysen, Laetitia; Kalombo, Lonji; Ramalapa, Bathabile; Hayeshi, Rose; Swai, Hulda (Elsevier B.V., 2012-03-15)
    The surface of nanoparticles is often functionalised with polymeric surfactants, in order to increase systemic circulation time. This has been investigated mainly for intravenously administered nanoparticles. This study ...
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    Oral lipid-based nanoformulation of tafenoquine enhanced bioavailability and blood stage antimalarial efficacy and led to a reduction in human red blood cell loss in mice 

    Melariri, Paula; Kalombo, Lonji; Nkuna, Patric; Dube, Admire; Hayeshi, Rose; Ogutu, Benhards; Gibhard, Liezl; deKock, Carmen; Smith, Peter; Wiesner, Lubbe; Swai, Hulda (Dovepress, 2015-02-20)
    : Tafenoquine (TQ), a new synthetic analog of primaquine, has relatively poor bioavailability and associated toxicity in glucose-6-phosphate dehydrogenase (G6PD)-deficient individuals. A microemulsion formulation of TQ ...
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    Effects of spray-drying on w/o/w multiple emulsions prepared from a stearic acid matrix 

    Mlalila, Nichrous; Swai, Hulda; Kalombo, Lonji; Hilonga, Askwar (2014-01-01)
    The goal of this study was to explore the effects of spray-drying on w/o/w double emulsions of methyltestosterone (MT) loaded in a stearic acid matrix. MT-loaded nanoparticles were formulated by a water-in-oil-in-water ...
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    Design and formulation of nano-sized spray dried efavirenz-part I: influence of formulation parameters 

    Katata, Lebogang; Tshweu, Lesego; Naidoo, Saloshnee; Kalombo, Lonji; Swai, Hulda (Springer Nature Switzerland AG., 2012-10-25)
    Efavirenz (EFV) is one of the first-line antiretroviral drugs recommended by the World Health Organisation for treating HIV. It is a hydrophobic drug that suffers from low aqueous solubility (4 μg/mL), which leads to a ...
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    Nanoencapsulation of water-soluble drug, lamivudine, using a double emulsion spray-drying technique for improving HIV treatment 

    Tshweu, Lesego; Katata, Lebogang; Kalombo, Lonji; Swai, Hulda (Springer Nature Switzerland AG., 2013-10-22)
    Current treatments available for human immunodeficiency virus, namely antiretrovirals, do not completely eradicate the virus from the body, leading to life-time commitment. Many antiretrovirals suffer drawbacks from ...
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    Spray-Dried, Nanoencapsulated, Multi-Drug Anti-Tuberculosis Therapy Aimed at OnceWeekly Administration for the Duration of Treatment 

    Kalombo, Lonji; Lemmer, Yolandy; Semete-Makokotlela, Boitumelo; Ramalapa, Bathabile; Nkuna, Patric; Booysen, Laetitia; Naidoo, Saloshnee; Hayeshi, Rose; Verschoor, Jan; Swai, Hulda (MDPI, 2019-08-15)
    Aiming to improve the treatment outcomes of current daily tuberculosis (TB) chemotherapy over several months, we investigated whether nanoencapsulation of existing drugs would allow decreasing the treatment frequency to ...
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    Human food safety and environmental hazards associated with the use of methyltestosterone and other steroids in production of all-male tilapia 

    Mlalila, Nichrous; Mahika, Charles; Kalombo, Lonji; Swai, Hulda; Hilonga, Askwar (Springer, 2015-04)
    In recent years, all-male cultures of Nile tilapia (Oreochromis niloticus) have been the most preferred mode of production in aquaculture industry. All-male individuals achieve higher somatic growth rate and shut high ...
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    Development, characterization and antimalarial efficacy of dihydroartemisinin loaded solid lipid nanoparticles. 

    Omwoyo, Wesley; Melariri, Paula; Gathirwa, Jeremiah; Oloo, Florence; Mahanga, Geoffrey; Kalombo, Lonji; Ogutu, Bernhards; Swai, Hulda (Elsevier, 2016-04-01)
    Effective use of dihydroartemisinin (DHA) is limited by poor water-solubility, poor pharmacokinetic profile and unsatisfactory clinical outcome especially in monotherapy. To reduce such limitations, we reformulated DHA ...
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    Enhanced oral bioavailability of the antiretroviral efavirenz encapsulated in poly(epsilon-caprolactone) nanoparticles by a spray-drying method. 

    Tshweu, Lesego; Katata, Lebogang; Kalombo, Lonji; Chiappetta, Diego; Hocht, Christian; Sosnik, Alejandro; Swai, Hulda (NANOMEDICINE, 2014-10-17)
    Aim: To encapsulate efavirenz (EFV) within poly(epsilon-caprolactone) (PCL) nanoparticles (NPs) and compare the oral pharmacokinetics with that of EFV-loaded micelles and pure EFV NPs. Materials & methods: EFV-loaded PCL ...
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    State of the art and future directions in nanomedicine for tuberculosis. 

    Dube, Admire; Lemmer, Yolandy; Hayeshi, Rose; Balogun, Mohammed; Labuschagne, Philip; Swai, Hulda; Kalombo, Lonji (Expert Opinion on Drug Delivery, 2013-12-01)
    Introduction: Tuberculosis (TB) ranks the second leading cause of death from an infectious disease worldwide. However, treatment of TB is affected by poor patient compliance due to the requirement for daily drug administration, ...
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    Kalombo, Lonji (15)
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    Hayeshi, Rose (4)Booysen, Laetitia (3)Katata, Lebogang (3)Lemmer, Yolandy (3)Melariri, Paula (3)Ramalapa, Bathabile (3)Semete-Makokotlela, Boitumelo (3)Tshweu, Lesego (3)... View MoreSubjectNanoparticles (3)Efavirenz (2)17α-Methyltestosterone (1)Biodistribution (1)Biotransformation (1)Dihydroartemisinin (1)dose frequency (1)Double emulsion (1)double emulsion (1)double emulsions (1)... View MoreDate Issued2010 - 2019 (14)2008 - 2009 (1)Has File(s)Yes (15)

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