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Effects of protein binding on the biodistribution of PEGylated PLGA nanoparticles post oral administration
(Elsevier B.V., 2012-03-15)
The surface of nanoparticles is often functionalised with polymeric surfactants, in order to increase systemic circulation time. This has been investigated mainly for intravenously administered nanoparticles. This study ...
Oral lipid-based nanoformulation of tafenoquine enhanced bioavailability and blood stage antimalarial efficacy and led to a reduction in human red blood cell loss in mice
(Dovepress, 2015-02-20)
: Tafenoquine (TQ), a new synthetic analog of primaquine, has relatively poor
bioavailability and associated toxicity in glucose-6-phosphate dehydrogenase (G6PD)-deficient
individuals. A microemulsion formulation of TQ ...
State of the art and future directions in nanomedicine for tuberculosis.
(Expert Opinion on Drug Delivery, 2013-12-01)
Introduction: Tuberculosis (TB) ranks the second leading cause of death from an infectious disease worldwide. However, treatment of TB is affected by poor patient compliance due to the requirement for daily drug administration, ...
Spray-Dried, Nanoencapsulated, Multi-Drug Anti-Tuberculosis Therapy Aimed at OnceWeekly Administration for the Duration of Treatment
(MDPI, 2019-08-15)
Aiming to improve the treatment outcomes of current daily tuberculosis (TB) chemotherapy
over several months, we investigated whether nanoencapsulation of existing drugs would allow
decreasing the treatment frequency to ...