Research Articles [LISBE]: Recent submissions
Now showing items 721-740 of 886
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Larvicidal potential of wild mushroom extracts against Culex quinquefasciatus Say, Aedes aegypti and Anopheles gambiae Giles S.S
(American Journal of Research Communication, 2014)The crude extracts from six wild mushrooms namely Lactarius densifolius, Lactarius gymnocarpoides, Russula cellulata, Russula kivuensis, Amanita phalloides and Boletus species were evaluated for larvicidal activity against ... -
Molecular detection and genetic characterization of Bartonella species from rodents and their associated ectoparasites from northern Tanzania
(PLOS ONE, 2019-10-15)Background Bartonellae are intracellular bacteria, which can cause persistent bacteraemia in humans and a variety of animals. Several rodent-associated Bartonella species are human pathogens but data on their global ... -
Antimalarial activity of Cucumis metuliferus and Lippia kituiensis against Plasmodium berghei infection in mice
(Dovepress, 2018)Background: The search for new antimalarial drugs has become progressively urgent due to plasmodial resistance to most of the commercially available antimalarial drugs. As part of this effort, the study evaluated the ... -
Spray-Dried, Nanoencapsulated, Multi-Drug Anti-Tuberculosis Therapy Aimed at OnceWeekly Administration for the Duration of Treatment
(MDPI, 2019-08-15)Aiming to improve the treatment outcomes of current daily tuberculosis (TB) chemotherapy over several months, we investigated whether nanoencapsulation of existing drugs would allow decreasing the treatment frequency to ... -
Polyamidoamine Dendrimers for Enhanced Solubility of Small Molecules and Other Desirable Properties for Site Specific Delivery: Insights from Experimental and Computational Studies
(MDPI, 2018-06-12)Clinical applications of many small molecules are limited due to poor solubility and lack of controlled release besides lack of other desirable properties. Experimental and computational studies have reported on the ... -
In vivo uptake and acute immune response to orally administered chitosan and PEG coated PLGA nanoparticles
(Elsevier, 2010-09-17)Nanoparticulate drug delivery systems offer great promise in addressing challenges of drug toxicity, poor bioavailability and non-specificity for a number of drugs. Much progress has been reported for nano drug delivery ... -
Preparation, characterization, and optimization of primaquine-loaded solid lipid nanoparticles
(Dovepress, 2014-08-11)Primaquine (PQ) is one of the most widely used antimalarial drugs and is the only available drug that combats the relapsing form of malaria. PQ use in higher doses is limited by severe tissue toxicity including hematological- ... -
Curdlan-Conjugated PLGA Nanoparticles Possess Macrophage Stimulant Activity and Drug Delivery Capabilities
(Springer, 2015-03-28)Purpose There is significant interest in the application of nanoparticles to deliver immunostimulatory signals to cells.We hypothesized that curdlan (immune stimulating polymer) could be conjugated to PLGA and nanoparticles ... -
Comparative in vitro transportation of pentamidine across the blood-brain barrier using polycaprolactone nanoparticles and phosphatidylcholine liposomes
(Taylor & Francis Group., 2019-04-22)Nanoparticles (NPs) have gained importance in addressing drug delivery challenges across biological barriers. Here, we reformulated pentamidine, a drug used to treat Human African Trypanosomiasis (HAT) in polymer based ... -
A polymeric system for the intra-oral delivery of an anti-fungal agent
(Elsevier Science Ltd., 2001)Oral candidal infections are often persistent and intractable and thus the aim of this study was to develop a polymeric sustained release device to improve the topical treatment of these infections. A self curing system ... -
Mycolic acids, a promising mycobacterial ligand for targeting of nanoencapsulated drugs in tuberculosis
(Elsevier, 2015-06-06)The appearance of drug-resistant strains of Mycobacterium tuberculosis (Mtb) poses a great challenge to the development of novel treatment programmes to combat tuberculosis. Since innovative nanotechnologiesmight ... -
The Sero-epidemiology of Neospora caninum in Cattle in Northern Tanzania
(Frontiers in Veterinary Science, 2019-09-26)Neospora caninum is a protozoan intracellular parasite of animals with a global distribution. Dogs act as definitive hosts, with infection in cattle leading to reproductive losses. Neosporosis can be a major source of ... -
iMAP: an integrated bioinformatics and visualization pipeline for microbiome data analysis
(BMC Bioinformatics, 2019)Background: One of the major challenges facing investigators in the microbiome field is turning large numbers of reads generated by next-generation sequencing (NGS) platforms into biological knowledge. Effective analytical ... -
The impact of malignant catarrhal fever virus challenge on physiological stress in cattle
(American Journal of Research Communication, 2014)There is a lot of information in literature on animals succumbing to disease(s) after exposure to stressors. But little information is available on what happens to corticosterone hormones when animals are exposed to a ... -
The genetic diversity of local african chickens: A potential for selection of chickens resistant to viral infections
(Poultry Science Association Inc., 2018)Viral infections impose a great threat to backyard chicken production among poor rural households in developing countries. These infections limit the contribution of chicken production in improving the livelihoods of ... -
Solvent effects on molecular encapsulation of Toussantine-A by chitosan nanoparticle: A metadynamics study
(Elsevier, 2019-10-15)We report a metadynamics study of toussantine-A with chitosan nanoparticle in dimethyl sulfoxide and water in order to assess the solvent related effects on free energy and interaction stability between the two compounds. ... -
Potential of treating tuberculosis with a polymeric nano-drug delivery system
(Elsevier, 2008-12-18)An effective therapeutic regimen is available for the treatment of tuberculosis (TB), however in developing countries; patient non-compliance due to high dose frequency and the lengthy duration of treatment, presents a ... -
Human food safety and environmental hazards associated with the use of methyltestosterone and other steroids in production of all-male tilapia
(Springer, 2015-04)In recent years, all-male cultures of Nile tilapia (Oreochromis niloticus) have been the most preferred mode of production in aquaculture industry. All-male individuals achieve higher somatic growth rate and shut high ... -
Modifications of the hydrophilicity of heterocyclic methacrylate copolymers for protein release
(Elsevier, 1995-12)A series of copolymers comprising ethyl methacrylate (EM) and tetrahydrofurfuryl methacrylate (THFMA) gelled with either THFMA monomer or hydroxyethyl methacrylate (HEMA) monomer have been developed. In this paper, we ... -
Enhanced oral bioavailability of the antiretroviral efavirenz encapsulated in poly(epsilon-caprolactone) nanoparticles by a spray-drying method.
(NANOMEDICINE, 2014-10-17)Aim: To encapsulate efavirenz (EFV) within poly(epsilon-caprolactone) (PCL) nanoparticles (NPs) and compare the oral pharmacokinetics with that of EFV-loaded micelles and pure EFV NPs. Materials & methods: EFV-loaded PCL ...
