Browsing Materials, Energy, Water and Environmental Sciences by Author "Paul, Lucas"
Now showing items 1-4 of 4
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A computer-based approach for developing linamarase inhibitory agents
Paul, Lucas; Mudogo, Celestin; Mtei, Kelvin; Machunda, Revocatus; Ntie-Kang, Fidele (Walter de Gruyter GmbH, 2020-04-18)Cassava is a strategic crop, especially for developing countries. However, the presence of cyanogenic compounds in cassava products limits the proper nutrients utilization. Due to the poor availability of structure discovery ... -
A Molecular Investigation of the Solvent Influence on Inter- and Intra-Molecular Hydrogen Bond Interaction of Linamarin
Paul, Lucas; Deogratias, Geradius; Shadrack, Daniel; Mudogo, Celestin; Mtei, Kelvin; Machunda, Revocatus; Paluch, Andrew; Ntie‐Kang, Fidele (MDPI, 2022-02-11)Linamarin has been reported to have anticancer activities; however, its extraction and isolation using different solvents yield a low amount. Therefore, understanding the physical prop‐ erties, such as solvents’ solubility, ... -
Structural and biophysical characterization of cassava linamarase and the role of solvents on linamarin’s properties: a computational study
Paul, Lucas (NM-AIST, 2022-06)Linamarase and linamarin mainly from cassava have many applications ranging from food, environmental to the medical industry. To better explore the potential of this enzyme and its substrate, one needs to understand ... -
Structural characterization of cassava linamarase-linamarin enzyme complex: an integrated computational approach
Paul, Lucas; Shadrack, Daniel; Mudogo, Celestin; Mtei, Kelvin; Machunda, Revocatus; Ntie‐Kang, Fidele (Taylor & Francis Group, 2021-05-21)Cassava linamarase is a hydrolyzing enzyme that belongs to a glycoside hydrolase family 1 (GH1). It is responsible for breaking down linamarin to toxic cyanide. The enzyme provides a defensive mechanism for plants against ...