• Login
    View Item 
    •   NM-AIST Home
    • Life sciences and Bio-engineering
    • PhD Theses and Dissertations [LiSBE]
    • View Item
    •   NM-AIST Home
    • Life sciences and Bio-engineering
    • PhD Theses and Dissertations [LiSBE]
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Prevalence and risk factors for Q fever, spotted fever group rickettsioses, and typhus group rickettsioses in a pastoralist community of northern Tanzania, 2016–2017

    Thumbnail
    View/Open
    Full text (865.7Kb)
    Full text (865.7Kb)
    Date
    2024-01-12
    Author
    Moorthy, Ganga
    Rubach, Matthew
    Maze, Michael
    .Refuerzo, Regina
    Shirima, Gabriel
    Lukambagire, AbdulHamid
    Bodenham, Rebecca
    Goldwasser, Shama
    Thomas, Kate
    Sakasaka, Philoteus
    Mkenda, Nestory
    Bowhay, Thomas
    Perniciaro, Jamie
    Nicholson, William
    Kersh, Gilbert
    Kazwala, Rudovick
    Mmbaga, Blandina
    . Buza, Joram
    Maro, Venance
    Haydon, Daniel
    Crump, John
    Halliday, Jo
    Metadata
    Show full item record
    Abstract
    Background: In northern Tanzania, Q fever, spotted fever group (SFG) rickettsioses, and typhus group (TG) rickettsioses are common causes of febrile illness. We sought to describe the prevalence and risk factors for these zoonoses in a pastoralist community. Methods: Febrile patients ≥2 years old presenting to Endulen Hospital in the Ngorongoro Conservation Area were enrolled from August 2016 through October 2017. Acute andconvalescent blood samples were collected, and a questionnaire was administered. Sera were tested by immunofluorescent antibody (IFA) IgG assays using Coxiella burnetii (Phase II), Rickettsia africae, and Rickettsia typhi antigens. Serologic evidence of exposure was defined by an IFA titre ≥1:64; probable cases by an acute IFA titre ≥1:128; and confirmed cases by a ≥4-fold rise in titre between samples. Risk factors for exposure and acute case status were evaluated. Results: Of 228 participants, 99 (43.4%) were male and the median (interquartile range) age was 27 (16–41) years. Among these, 117 (51.3%) had C. burnetii exposure, 74 (32.5%) had probable Q fever, 176 (77.2%) had SFG Rickettsia exposure, 134 (58.8%) had probable SFG rickettsioses, 11 (4.8%) had TG Rickettsia exposure, and 4 (1.8%) had probable TG rickettsioses. Of 146 participants with paired sera, 1 (0.5%) had confirmed Q fever, 8 (5.5%) had confirmed SFG rickettsioses, and none had confirmed TG rickettsioses. Livestock slaughter was associated with acute Q fever (adjusted odds ratio [OR] 2.54, 95% confidence interval [CI] 1.38–4.76) and sheep slaughter with SFG rickettsioses case (OR 4.63, 95% CI 1.08–23.50). Discussion: Acute Q fever and SFG rickettsioses were detected in participants with febrile illness. Exposures to C. burnetii and to SFG Rickettsia were highly prevalent, and interactions with livestock were associated with increased odds of illness with both path- ogens. Further characterisation of the burden and risks for these diseases is warranted.
    URI
    https://dspace.nm-aist.ac.tz/handle/20.500.12479/2566
    Collections
    • PhD Theses and Dissertations [LiSBE]

    Nelson Mandela-AIST copyright © 2021  DuraSpace
    Theme by 
    Atmire NV
     

     

    Browse

    All PublicationsCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    Nelson Mandela-AIST copyright © 2021  DuraSpace
    Theme by 
    Atmire NV