Browsing by Author "Ishengoma, Deus"
Now showing items 1-4 of 4
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Molecular marker of Plasmodium falciparum resistance to chloroquine (Pfcrt) in an area with long history of antimalarial resistance
Shayo, Alex; Ishengoma, Deus; Baraka, Vito; Madebe, Rashid; Shahada, Francis; Buza, Joram (American Journal of Research Communication, 2014)Background High levels Plasmodium falciparum resistance to Chloroquine (CQ) compelled Tanzania to replace CQ with Suphadoxine-pyrimethamine (SP) as first-line antimalarial in 2001 which was however replaced with Artemether ... -
Monitoring of efficacy and safety of artemisininbased anti-malarials for treatment of uncomplicated malaria: a review of evidence of implementation of anti-malarial therapeutic efficacy trials in Tanzania
Shayo, Alex; Buza, Joram; Ishengoma, Deus (BioMed Central, 2015)Background: Prompt diagnosis and effective treatment are considered the cornerstones of malaria control and artemisinin-based combination therapy (ACT) is currently the main anti-malarial drugs used for case management. After ... -
Potential Opportunities and Challenges of Deploying Next Generation Sequencing and CRISPR-Cas Systems to Support Diagnostics and Surveillance Towards Malaria Control and Elimination in Africa
Lyimo, Beatus; Popkin-Hall, Zachary; Giesbrecht, David; Mandara, Celine; Madebe, Rashid; Bakari, Catherine; Pereus, Dativa; Seth, Misago; Ngamba, Ramadhan; Mbwambo, Ruth; MacInnis, Bronwyn; Mbwambo, Daniel; Garimo, Issa; Chacky, Frank; Aaron, Sijenunu; Lusasi, Abdallah; Molteni, Fabrizio; Njau, Ritha; Cunningham, Jane; Lazaro, Samwel; Mohamed, Ally; Juliano, Jonathan; Bailey, Jeffrey; Ishengoma, Deus (Frontiers, 2022-07-13)Recent developments in molecular biology and genomics have revolutionized biology and medicine mainly in the developed world. The application of next generation sequencing (NGS) and CRISPR-Cas tools is now poised to support ... -
Therapeutic efficacy and safety of artemether-lumefantrine for the treatment of uncomplicated falciparum malaria in North-Eastern Tanzania
Shayo, Alex; Mandara, Celine; Shahada, Francis; Buza, Joram; Lemnge, Martha; Ishengoma, Deus (BioMed Central, 2014)Background: The World Health Organization recommends that regular efficacy monitoring should be undertaken by all malaria endemic countries that have deployed artemisinin combination therapy (ACT). Although ACT is ...