Regeneration responses of Ankaferd Blood Stopper, platelet-rich-plasma, and Momordica charantia on sciatic nerve injury in the obese rats
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Date
2025-05-23
Journal Title
Journal ISSN
Volume Title
Publisher
IOP Publishing
Abstract
Obesity is a prevalent and potentially fatal disorder in industrialized nations, often due to an
imbalance between calorie intake and energy expenditure. The study investigates the effects of
Ankaferd Blood Stopper (ABS), platelet-rich plasma (PRP), and Momordica charantia (MC) on
obese rats with sciatic nerve injuries using stereological and electron microscopic techniques.
Twenty-four female Sprague Dawley rats, aged 8–10 weeks, were divided into three groups: the
obese gap ABS group (OGABS), the obese gap PRP group (OGPRP), and the obese gap MC group
(OGMC). Afive-mm nerve block was resected approximately 10 mm above the nerve branch. The
gap region was then surrounded and closed by a collagen membrane in tube form. Materials such as
ABS, PRP, and MCwere injected into the tubes of each group. Electromyography and histological
procedures were performed after 12 weeks of surgery to investigate their structural repair and
functional promotion of nerve regeneration. A significant increase in the number of myelinated
axons in OGMCwasfound.Inaddition, the latency values in OGMC were more critical than in the
OGABSandOGPRPgroups,indicating better myelination. PRP and ABS positively affected nerve
gap repair, favoring regenerating unmyelinated axons. Due to increased amplitude values, PRP and
ABS have also improved axonal area regeneration. Collagen tubes containing ABS, PRP, and MC
may help repair and close peripheral nerve gaps in obese rats, which could be beneficial in closing
peripheral nerve resection and demyelination. The study’s findings indicate that these collagen
tubes can have a therapeutic effect on peripheral nerve regeneration in obese models.
Sustainable Development Goals
SDG-3: Good Health and Well-being
SDG-9: Industry, Innovation, and Infrastructure
Keywords
Nerve regeneration, Obesity, Ankaferd blood stopper, Platelet-rich plasma, Momordica charantia, Stereology