Characterization of Polycaprolactone and Rice Husk Silica Composite (PCL-SiO2) by E-Spinning to Apply Supporter for Drug Release
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Date
2017
Authors
Song, Sinae
Hilonga, Askwar
Kim, Hee Taik
Journal Title
Journal ISSN
Volume Title
Publisher
IOP Publishing Ltd
Abstract
Abstract. Polycaprolactone (PCL) is an interesting material to apply biomedical field owing to
its biodegradability and biocompatibility which is suitable for a specific site with longer
healing times. Blending the polymer with other materials has degradation property improved
with the effective and economic method. This study was conducted to fabricate supporter based
on Polycaprolactone and Rice husk silica (PCL-SiO2) by using electrospinning. Nano-porous
silica in the composite was synthesized from rice husk having properties of economic, ecofriendly
and high surface area. It drew to enhance the amount of drug loading in the carrier.
Electrospinning technique is used to fabricate fibrous component by optimization condition
obtained from previous mechanical properties experiments. Release experiment was carried out
by the degree of dye absorbance at 544nm by ultraviolet–visible spectroscopy, the RhB in
SiO2 alternative drug for modelling of drug release was released for 1 ~ 20 days at 37°C in
phosphate buffer. Furthermore, the Mechanical property was confirmed by DSC, TGA.
Morphology and degree of biodegradation were shown as SEM images and EDS.
Sustainable Development Goals
SDG 3: Good Health and Well-Being, SDG 9: Industry, Innovation, and Infrastructure, SDG 9: Industry, Innovation, and Infrastructure.
Keywords
Research Subject Categories::NATURAL SCIENCES