Assessment of rectal dose with thermoluminescent in vivo dosimetry in high-dose-rate cobalt-60 intracavitary brachytherapy for cervical cancer: A two-arm cohort study using orthogonal images planning
| dc.contributor.author | Mlawa, Omega | |
| dc.contributor.author | Ngaile, Justin | |
| dc.contributor.author | Chaurasia, Pradumna | |
| dc.contributor.author | Amasi, Aloyce | |
| dc.date.accessioned | 2025-09-25T06:13:41Z | |
| dc.date.issued | 2025-05-07 | |
| dc.description | SDG-3: Good Health and Well-being SDG-9: Industry, Innovation, and Infrastructure | |
| dc.description.abstract | Purpose: High-dose-rate intracavitary brachytherapy delivers high radiation doses to tumors while minimizing exposure to surrounding normal cells. However, inappropriate administration can lead to radiation-induced toxicity by overdosing organs at risk. This study evaluated and compared the rectum doses planned by treatment planning system and measured using a thermoluminescent dosimeter. Material and methods: Thermoluminescent dosimeters (TLD) were employed to measure radiation dose to the rectum across two patient groups: one treated using first fraction-based planning (FFP), and the other with each fraction planned individually (EFP). Results: The mean dose measured by TLD (3.99 ±1.63 Gy) was higher than the mean dose planned by TPS (3.23 ±1.16 Gy, p < 0.001). The mean dose difference was higher in second fraction (0.87 ±1.89 Gy) for first fraction-based planning group; however, the differences between first and second fractions were not statistically significant in either group. Conclusions: For patients transferred from a brachytherapy couch to a hospital stretcher during applicator insertion and dose delivery, first fraction-based planning is feasible. However, caution is needed to minimize applicator shifts, as these changes can alter the geometric position between fractions. | |
| dc.identifier.uri | https://doi.org/10.5114/jcb.2025.150247 | |
| dc.identifier.uri | https://dspace.nm-aist.ac.tz/handle/123456789/3296 | |
| dc.language.iso | en | |
| dc.publisher | Journal of Contemporary Brachytherapy | |
| dc.subject | Intracavitary brachytherapy | |
| dc.subject | Cervical cancer | |
| dc.subject | Radiation dose | |
| dc.subject | Rectum | |
| dc.subject | Cobalt-60 | |
| dc.title | Assessment of rectal dose with thermoluminescent in vivo dosimetry in high-dose-rate cobalt-60 intracavitary brachytherapy for cervical cancer: A two-arm cohort study using orthogonal images planning | |
| dc.type | Article |