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dc.contributor.authorZuberi, Zavuga
dc.contributor.authorSauli, Elingarami
dc.contributor.authorCun, Liu
dc.contributor.authorDeng, Jing
dc.contributor.authorLi, Wen-Jun
dc.contributor.authorHe, Xu-Liang
dc.contributor.authorLi, Wen
dc.date.accessioned2020-08-11T08:10:15Z
dc.date.available2020-08-11T08:10:15Z
dc.date.issued2020-05-20
dc.identifier.urihttps://doi.org/10.1177%2F2042018820906016
dc.identifier.urihttps://dspace.nm-aist.ac.tz/handle/20.500.12479/862
dc.descriptionThis research article published by SAGE Publications Ltd., 2020en_US
dc.description.abstractEfforts directed toward restoring normal metabolic levels by mimicking the physiological insulin secretion, thereby ensuring safety, efficacy, minimal invasiveness and conveniences, are of great significance in the management of type 1 diabetes among children and adolescents. Regardless of the various technologies being discovered in addressing invasiveness and enhancing medication adherence in the management of type 1 diabetes, yet limited success had been observed among children and adolescents. The multiple daily subcutaneous insulin injections route using vial and syringe, and occasionally insulin pens, remain the most predictable route for insulin administration among children and adolescents. However, this route has been associated with compromised patient compliance, fear of injections and unacceptability, resulting in poor glycemic control, which promote the demand for alternative routes of insulin administration. Alternative routes for delivering insulin are being investigated in children and adolescents with type 1 diabetes; these include the hybrid closed-loop ‘artificial pancreas’ system, oral, inhalation, intranasal routes, and others. This review article explores the current advances in insulin-delivery methods that address the needs of children and adolescents in the treatment of type 1 diabetes.en_US
dc.language.isoenen_US
dc.publisherSAGE Publications Ltd.en_US
dc.subjectArtificial pancreasen_US
dc.subjectInsulin deliveryen_US
dc.subjectNasal insulinen_US
dc.subjectType 1 diabetesen_US
dc.titleInsulin-delivery methods for children and adolescents with type 1 diabetesen_US
dc.typeArticleen_US


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