Browsing Research Articles [LISBE] by Author "Kalombo, Lonji"
Now showing items 1-16 of 16
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Design and formulation of nano-sized spray dried efavirenz-part I: influence of formulation parameters
(Springer Nature Switzerland AG., 2012-10-25)Efavirenz (EFV) is one of the first-line antiretroviral drugs recommended by the World Health Organisation for treating HIV. It is a hydrophobic drug that suffers from low aqueous solubility (4 μg/mL), which leads to a ... -
Development, characterization and antimalarial efficacy of dihydroartemisinin loaded solid lipid nanoparticles.
(Elsevier, 2016-04-01)Effective use of dihydroartemisinin (DHA) is limited by poor water-solubility, poor pharmacokinetic profile and unsatisfactory clinical outcome especially in monotherapy. To reduce such limitations, we reformulated DHA ... -
Effects of protein binding on the biodistribution of PEGylated PLGA nanoparticles post oral administration
(Elsevier B.V., 2012-03-15)The surface of nanoparticles is often functionalised with polymeric surfactants, in order to increase systemic circulation time. This has been investigated mainly for intravenously administered nanoparticles. This study ... -
Effects of spray-drying on w/o/w multiple emulsions prepared from a stearic acid matrix
(2014-01-01)The goal of this study was to explore the effects of spray-drying on w/o/w double emulsions of methyltestosterone (MT) loaded in a stearic acid matrix. MT-loaded nanoparticles were formulated by a water-in-oil-in-water ... -
Enhanced oral bioavailability of the antiretroviral efavirenz encapsulated in poly(epsilon-caprolactone) nanoparticles by a spray-drying method.
(NANOMEDICINE, 2014-10-17)Aim: To encapsulate efavirenz (EFV) within poly(epsilon-caprolactone) (PCL) nanoparticles (NPs) and compare the oral pharmacokinetics with that of EFV-loaded micelles and pure EFV NPs. Materials & methods: EFV-loaded PCL ... -
Human food safety and environmental hazards associated with the use of methyltestosterone and other steroids in production of all-male tilapia
(Springer, 2015-04)In recent years, all-male cultures of Nile tilapia (Oreochromis niloticus) have been the most preferred mode of production in aquaculture industry. All-male individuals achieve higher somatic growth rate and shut high ... -
In vivo evaluation of the biodistribution and safety of PLGA nanoparticles as drug delivery systems
(Elsevier Inc., 2010-10)The remarkable physicochemical properties of particles in the nanometer range have been proven to address many challenges in the field of science. However, the possible toxic effects of these particles have raised some ... -
In vivo/in vitro pharmacokinetic and pharmacodynamic study of spray-dried poly-(dl-lactic-co-glycolic) acid nanoparticles encapsulating rifampicin and isoniazid.
(Elsevier B.V., 2013-02-28)Poly-(dl-lactic-co-glycolic) acid (PLGA) nanoparticles were prepared by a double emulsion solvent evaporation spray-drying technique and coated with polyethylene glycol (PEG 1% v/v). The PLGA nanoparticles had a small size ... -
Mycolic acids, a promising mycobacterial ligand for targeting of nanoencapsulated drugs in tuberculosis
(Elsevier, 2015-06-06)The appearance of drug-resistant strains of Mycobacterium tuberculosis (Mtb) poses a great challenge to the development of novel treatment programmes to combat tuberculosis. Since innovative nanotechnologiesmight ... -
Nanoencapsulation of water-soluble drug, lamivudine, using a double emulsion spray-drying technique for improving HIV treatment
(Springer Nature Switzerland AG., 2013-10-22)Current treatments available for human immunodeficiency virus, namely antiretrovirals, do not completely eradicate the virus from the body, leading to life-time commitment. Many antiretrovirals suffer drawbacks from ... -
Oral lipid-based nanoformulation of tafenoquine enhanced bioavailability and blood stage antimalarial efficacy and led to a reduction in human red blood cell loss in mice
(Dovepress, 2015-02-20): Tafenoquine (TQ), a new synthetic analog of primaquine, has relatively poor bioavailability and associated toxicity in glucose-6-phosphate dehydrogenase (G6PD)-deficient individuals. A microemulsion formulation of TQ ... -
Potential of treating tuberculosis with a polymeric nano-drug delivery system
(Elsevier, 2008-12-18)An effective therapeutic regimen is available for the treatment of tuberculosis (TB), however in developing countries; patient non-compliance due to high dose frequency and the lengthy duration of treatment, presents a ... -
Preparation of rifampicin/lactose microparticle composites by a supercritical antisolvent-drug excipient mixing technique for inhalation delivery
(Elsevier, 2013-02)Rifampicin (RIF) is precipitated in the presence of inhalable lactose particles using a supercritical antisolvent-drug excipient mixing (SAS-DEM) technique to create RIF/lactose microparticle composites intended to improve ... -
Preparation, characterization, and optimization of primaquine-loaded solid lipid nanoparticles
(Dovepress, 2014-08-11)Primaquine (PQ) is one of the most widely used antimalarial drugs and is the only available drug that combats the relapsing form of malaria. PQ use in higher doses is limited by severe tissue toxicity including hematological- ... -
Spray-Dried, Nanoencapsulated, Multi-Drug Anti-Tuberculosis Therapy Aimed at OnceWeekly Administration for the Duration of Treatment
(MDPI, 2019-08-15)Aiming to improve the treatment outcomes of current daily tuberculosis (TB) chemotherapy over several months, we investigated whether nanoencapsulation of existing drugs would allow decreasing the treatment frequency to ... -
State of the art and future directions in nanomedicine for tuberculosis.
(Expert Opinion on Drug Delivery, 2013-12-01)Introduction: Tuberculosis (TB) ranks the second leading cause of death from an infectious disease worldwide. However, treatment of TB is affected by poor patient compliance due to the requirement for daily drug administration, ...
