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Association of LEI0258 Marker Alleles and Susceptibility to Virulent Newcastle Disease Virus Infection in Kuroiler, Sasso, and Local Tanzanian Chicken Embryos.

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dc.contributor.author Mpenda, Fulgence Ntangere
dc.contributor.author Tiambo, Christian Keambou
dc.contributor.author Kyallo, Martina
dc.contributor.author Juma, John
dc.contributor.author Pelle, Roger
dc.contributor.author Lyantagaye, Sylvester Leonard
dc.contributor.author Buza, Joram
dc.date.accessioned 2020-06-12T08:12:32Z
dc.date.available 2020-06-12T08:12:32Z
dc.date.issued 2020-04-08
dc.identifier.uri https://doi.org/10.1155/2020/5187578
dc.identifier.uri https://dspace.nm-aist.ac.tz/handle/20.500.12479/790
dc.description This research article published by Hindawi, 2020 en_US
dc.description.abstract Newcastle disease (ND) control by vaccination and an institution of biosecurity measures is less feasible in backyard chicken in developing countries. Therefore, an alternative disease control strategy like the genetic selection of less susceptible chicken genotypes is a promising option. In the present study, genetic polymorphism of LEIO258 marker and association with susceptibility to virulent Newcastle disease virus (NDV) infection in Kuroilers, Sasso, and local Tanzanian chicken embryos were investigated. Samples from high (15%) and less (15%) susceptible cohorts were genotyped by sequencing of LEI0258 marker. A total of 75 DNA sequences comprised of 29 Kuroiler, 29 local Tanzanian chickens, and 17 Sasso were analyzed. Neighbor-joining phylogenetic trees were constructed to depict the clustering of LEI0258 marker alleles and relationship with susceptibility. Alleles with frequency ≥3 were considered for association with susceptibility by the use of the inference technique. The present findings suggest that some LEI0258 marker genetic polymorphisms apart from LEI0258 marker allelic based on sizes may be linked with chicken MHC-B haplotypes that confer chickens variability in resistance or susceptibility to infections. Furthermore, these results demonstrate the presence of relationship between LEI0258 marker polymorphisms and variations in chicken susceptibility to NDV infection, which could be utilized in breeding programs designed to improve chicken disease resistance. en_US
dc.language.iso en en_US
dc.publisher Hindawi en_US
dc.subject Research Subject Categories::NATURAL SCIENCES en_US
dc.title Association of LEI0258 Marker Alleles and Susceptibility to Virulent Newcastle Disease Virus Infection in Kuroiler, Sasso, and Local Tanzanian Chicken Embryos. en_US
dc.type Article en_US


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