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dc.contributor.authorVianney, John-Mary
dc.contributor.authorMcCullough, Monica J.
dc.contributor.authorGyorkos, Amy M.
dc.contributor.authorSpitsbergen, John M.
dc.date.accessioned2020-02-12T06:45:51Z
dc.date.available2020-02-12T06:45:51Z
dc.date.issued2012
dc.identifier.uriDOI 10.1007/s11515-012-1201-7
dc.identifier.urihttp://dspace.nm-aist.ac.tz/handle/123456789/550
dc.descriptionThis research articles published by Higher Education Press and Springer-Verlag Berlin Heidelberg, 2012en_US
dc.description.abstractThe focus of this review is to highlight the importance of glial cell line-derived neurotrophic factor (GDNF) for the motor nervous system. GDNF is the most potent survival factor for motor neurons, where it enhances maintenance and survival of both developing and mature motor neurons in vivo and in vitro. GDNF aids in neuromuscular junction formation, maintenance, and plasticity, where skeletal muscle-derived GDNF may be responsible for this phenomenon. Increased levels of physical activity can increase GDNF protein levels in skeletal muscle, where alterations in acetylcholine and acetylcholine receptor activation may be involved in regulation of these changes observed. With inactivity and disuse, GDNF expression shows different patterns of regulation in the central and peripheral nervous systems. Due to its potent effects for motor neurons, GDNF is being extensively studied in neuromuscular diseases.en_US
dc.language.isoenen_US
dc.publisherHigher Education Press and Springer-Verlag Berlin Heidelbergen_US
dc.subjectglial cell line-derived neurotrophic factoren_US
dc.subjectneuromuscular junctionen_US
dc.subjectmotor neuronsen_US
dc.subjectskeletal muscleen_US
dc.titleExercise-dependent regulation of glial cell line-derived neurotrophic factor (GDNF) expression in skeletal muscle and its importance for the neuromuscular systemen_US
dc.typeArticleen_US


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