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dc.contributor.authorKalombo, Lonji
dc.contributor.authorLemmer, Yolandy
dc.contributor.authorSemete-Makokotlela, Boitumelo
dc.contributor.authorRamalapa, Bathabile
dc.contributor.authorNkuna, Patric
dc.contributor.authorBooysen, Laetitia
dc.contributor.authorNaidoo, Saloshnee
dc.contributor.authorHayeshi, Rose
dc.contributor.authorVerschoor, Jan
dc.contributor.authorSwai, Hulda
dc.date.accessioned2019-10-18T10:50:58Z
dc.date.available2019-10-18T10:50:58Z
dc.date.issued2019-08-15
dc.identifier.uridoi:10.3390/nano9081167
dc.identifier.urihttp://dspace.nm-aist.ac.tz/handle/123456789/509
dc.descriptionResearch Article published by MDPIen_US
dc.description.abstractAiming to improve the treatment outcomes of current daily tuberculosis (TB) chemotherapy over several months, we investigated whether nanoencapsulation of existing drugs would allow decreasing the treatment frequency to weekly, thereby ultimately improving patient compliance. Nanoencapsulation of three first-line anti-TB drugs was achieved by a unique, scalable spray-drying technology forming free-flowing powders in the nanometer range with encapsulation e ciencies of 82, 75, and 62% respectively for rifampicin, pyrazinamide, and isoniazid. In a pre-clinical study on TB infected mice, we demonstrate that the encapsulated drugs, administered once weekly for nine weeks, showed comparable e cacy to daily treatment with free drugs over the same experimental period. Both treatment approaches had equivalent outcomes for resolution of inflammation associated with the infection of lungs and spleens. These results demonstrate how scalable technology could be used to manufacture nanoencapsulated drugs. The formulations may be used to reduce the oral dose frequency from daily to once weekly in order to treat uncomplicated TB.en_US
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.subjectnanomedicineen_US
dc.subjectspray-drying technologyen_US
dc.subjectdose frequencyen_US
dc.titleSpray-Dried, Nanoencapsulated, Multi-Drug Anti-Tuberculosis Therapy Aimed at OnceWeekly Administration for the Duration of Treatmenten_US
dc.typeArticleen_US


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