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Conserved, breed-dependent, and subline-dependent innate immune responses of Fayoumi and Leghorn chicken embryos to Newcastle disease virus infection.

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dc.contributor.author Schilling, Megan A
dc.contributor.author Memari, Sahar
dc.contributor.author Cavanaugh, Meredith
dc.contributor.author Katani, Robab
dc.contributor.author Deist, Melissa S
dc.contributor.author Radzio-Basu, Jessica
dc.contributor.author Lamont, Susan J
dc.contributor.author Buza, Joram
dc.contributor.author Kapur, Vivek
dc.date.accessioned 2019-07-25T12:22:50Z
dc.date.available 2019-07-25T12:22:50Z
dc.date.issued 2019-05-10
dc.identifier.other 31076577
dc.identifier.uri https://doi.org/10.1038/s41598-019-43483-1
dc.identifier.uri http://dspace.nm-aist.ac.tz/handle/123456789/383
dc.description Research Article published by Scientific Reports en_US
dc.description.abstract Newcastle disease virus (NDV) is a threat to the global poultry industry, but particularly for smallholder farmers in low- and middle-income countries. Previous reports suggest that some breeds of chickens are less susceptible to NDV infection, however, the mechanisms contributing to this are unknown. We here examined the comparative transcriptional responses of innate immune genes to NDV infection in inbred sublines of the Fayoumi and Leghorn breeds known to differ in their relative susceptibility to infection as well as at the microchromosome bearing the major histocompatability complex (MHC) locus. The analysis identified a set of five core genes, Mx1, IRF1, IRF7, STAT1, and SOCS1, that are up-regulated regardless of subline. Several genes were differentially expressed in a breed- or subline-dependent manner. The breed-dependent response involved TLR3, NOS2, LITAF, and IFIH1 in the Fayoumi versus IL8, CAMP, and CCL4 in the Leghorn. Further analysis identified subline-dependent differences in the pro-inflammatory response within the Fayoumi breed that are likely influenced by the MHC. These results have identified conserved, breed-dependent, and subline-dependent innate immune responses to NDV infection in chickens, and provide a strong framework for the future characterization of the specific roles of genes and pathways that influence the susceptibility of chickens to NDV infection. en_US
dc.language.iso en en_US
dc.publisher Scientific Reports en_US
dc.subject Research Subject Categories::NATURAL SCIENCES en_US
dc.title Conserved, breed-dependent, and subline-dependent innate immune responses of Fayoumi and Leghorn chicken embryos to Newcastle disease virus infection. en_US
dc.type Article en_US


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