• Login
    View Item 
    •   NM-AIST Home
    • Life sciences and Bio-engineering
    • Research Articles [LISBE]
    • View Item
    •   NM-AIST Home
    • Life sciences and Bio-engineering
    • Research Articles [LISBE]
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Field vaccination of locally-owned cattle against malignant catarrhal fever under environmentally challenging conditions in Tanzania

    Thumbnail
    View/Open
    Full text (6.111Mb)
    Date
    2025-01-25
    Author
    Bainbridge, Samuel
    Mappi, Tauta
    Cleaveland, Sarah
    Chubwa, Choby
    Davis, Alicia
    Grant, Dawn
    Kibona, Tito
    Bwatota, Shedrack
    Larsen, Freja
    Lyimo, Samson
    Mshana, Fadhili
    Percival, Ann
    Shirima, Gabriel
    Mtili, Bakari
    Musyangi, Felix
    Tarimo, Rigobert
    Lankester, Felix
    Russell, George
    Metadata
    Show full item record
    Abstract
    Malignant catarrhal fever (MCF), caused by alcelaphine herpesvirus-1 (AIHV-1) transmitted from wildebeest, is a lethal cattle disease with significant impacts on East African pastoralists. Development of a live attenuated MCF vaccine has prompted research into its use in communities at risk. This study reports results from the first utilisation of the MCF vaccine in locally-owned cattle under field conditions. The study involved a primary two-dose course vaccination of 1634 cattle, followed a year later, by boost vaccination of 385 of these cattle. It aimed to: (a) evaluate the antibody response to a two-dose AlHV-1 primary vaccination course, including initial response, antibody levels after one year, and clinical events post-vaccination; (b) assess how factors like age, reproductive status, body condition, and breed influence the initial response; and (c) compare antibody responses to single- and two-dose booster protocols one year after primary vaccination. Analyses were carried out using linear mixed-effects models and paired t-tests. Clinical incidents were reported in 11/1634 cattle vaccinated during the primary course and in 0/385 cattle during the boost regimens. The primary vaccination resulted in a 9-fold increase in comparison to pre-vaccination antibody levels and the response was consistent across animals of different ages, reproductive statuses and body conditions. While antibody levels declined 11 months after primary vaccination, they remained high, and a single-dose booster vaccination was sufficient to elicit a strong immune response, with only marginal increases after a second booster. The study provides evidence of high immunogenicity and low incidences of clinical events of the vaccine in cattle across individual host factors and immunologically vulnerable groups, under prevailing environmental conditions. It also indicates the utility of a single-dose booster regimen. These findings will support progress towards commercial production and larger-scale adoption which could generate important benefits for the livelihoods, and sustainability of pastoral livestock systems.
    URI
    https://doi.org/10.1016/j.vaccine.2024.126587
    https://dspace.nm-aist.ac.tz/handle/20.500.12479/2995
    Collections
    • Research Articles [LISBE]

    Nelson Mandela-AIST copyright © 2021  DuraSpace
    Theme by 
    Atmire NV
     

     

    Browse

    All PublicationsCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    Nelson Mandela-AIST copyright © 2021  DuraSpace
    Theme by 
    Atmire NV