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    Empirical and model-based evidence for a negligible role of cattle in peste des petits ruminants virus transmission and eradication

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    Date
    2024-08-03
    Author
    Herzog, Catherine
    Aklilu, Fasil
    Sibhatu, Demeke
    Shegu, Dereje
    Belaineh, Redeat
    Mohammed, Abde
    Schulz, Claudia
    Willett, Brian
    Bailey, Dalan
    Hudson, Peter
    Buza, Joram
    Forza, Mesfin
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    Abstract
    Peste des petits ruminants virus (PPRV) is a multi-host pathogen with sheep and goats as main hosts. To investigate the role of cattle in the epidemiology of PPR, we simulated conditions similar to East African zero-grazing husbandry practices in a series of trials with local Zebu cattle (Bos taurus indicus) co-housed with goats (Capra aegagrus hircus). Furthermore, we developed a mathematical model to assess the impact of PPRV-transmission from cattle to goats. Of the 32 cattle intranasally infected with the locally endemic lineage IV strain PPRV/Ethiopia/Habru/2014 none transmitted PPRV to 32 co-housed goats. However, these cattle or cattle co-housed with PPRV-infected goats seroconverted. The results confirm previous studies that cattle currently play a negligible role in PPRV-transmission and small ruminant vaccination is sufficient for eradication. However, the possible emergence of PPRV strains more virulent for cattle may impact eradication. Therefore, continued monitoring of PPRV circulation and evolution is recommended.
    URI
    https://doi.org/10.1038/s42003-024-06619-2
    https://dspace.nm-aist.ac.tz/handle/20.500.12479/2866
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