| dc.description.abstract | Brucellosis is a zoonotic infection caused by Gram-negative bacteria of genus Brucella. The disease is of public health, veterinary,
and economic significance in most of the developed and developing countries. Direct contact between susceptible and infective
animals or their contaminated products are the two major routes of the disease transmission. In this paper, we investigate the
impacts of controls of livestock vaccination, gradual culling through slaughter of seropositive cattle and small ruminants,
environmental hygiene and sanitation, and personal protection in humans on the transmission dynamics of Brucellosis. The
necessary conditions for an optimal control problem are rigorously analyzed using Pontryagin’s maximum principle. The main
ambition is to minimize the spread of brucellosis disease in the community as well as the costs of control strategies. Findings
showed that the effective use of livestock vaccination, gradual culling through slaughter of seropositive cattle and small ruminants,
environmental hygiene and sanitation, and personal protection in humans have a significant impact in minimizing the disease
spread in livestock and human populations. Moreover, cost-effectiveness analysis of the controls showed that the combination of
livestock vaccination, gradual culling through slaughter, environmental sanitation, and personal protection in humans has high
impact and lower cost of prevention. | en_US |
