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The neoplastically transformed (CD30hi) Marek’s disease lymphoma cell phenotype most closely resembles T-regulatory cells

Shack, Leslie; Buza, Joram; Burgess, Shane (Springer-Verlag, 2008-02-07)

Introduction Marek’s disease (MD), a herpesvirus-induced lymphoma of chickens is a unique natural model of CD30- overexpressing (CD30hi) lymphoma. We have previously proposed that the CD30hi neoplastically transformed ...

Genotype-Dependent Tumor Regression in Marek’s Disease Mediated at the Level of Tumor Immunity

Kumar, Shyamesh; Buza, Joram; Burgess, Shane (Springer, 2008-03-18)

Marek’s disease (MD) of chickens is a unique natural model of Hodgkin’s and Non Hodgkin’s lymphomas in which the neoplastically-transformed cells over-express CD30 (CD30hi) antigen. All chicken genotypes can be infected ...