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    Design and formulation of nano-sized spray dried efavirenz-part I: influence of formulation parameters 

    Katata, Lebogang; Tshweu, Lesego; Naidoo, Saloshnee; Kalombo, Lonji; Swai, Hulda (Springer Nature Switzerland AG., 2012-10-25)
    Efavirenz (EFV) is one of the first-line antiretroviral drugs recommended by the World Health Organisation for treating HIV. It is a hydrophobic drug that suffers from low aqueous solubility (4 μg/mL), which leads to a ...
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    Enhanced oral bioavailability of the antiretroviral efavirenz encapsulated in poly(epsilon-caprolactone) nanoparticles by a spray-drying method. 

    Tshweu, Lesego; Katata, Lebogang; Kalombo, Lonji; Chiappetta, Diego; Hocht, Christian; Sosnik, Alejandro; Swai, Hulda (NANOMEDICINE, 2014-10-17)
    Aim: To encapsulate efavirenz (EFV) within poly(epsilon-caprolactone) (PCL) nanoparticles (NPs) and compare the oral pharmacokinetics with that of EFV-loaded micelles and pure EFV NPs. Materials & methods: EFV-loaded PCL ...

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    AuthorKalombo, Lonji (2)Katata, Lebogang (2)
    Swai, Hulda (2)
    Tshweu, Lesego (2)Chiappetta, Diego (1)Hocht, Christian (1)Naidoo, Saloshnee (1)Sosnik, Alejandro (1)Subject
    Efavirenz (2)
    HIV (1)In vitro drug release (1)Nanoparticles (1)Oral bioavailability enhancement (1)Poly(epsilon-caprolactone) nanoparticle (1)Polycaprolactone (1)Spray dried (1)Spray drying (1)Taguchi method (1)... View MoreDate Issued2012 (1)2014 (1)Has File(s)Yes (2)

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