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    Development of a Natural Product Rich in Bioavailable Omega-3 DHA from Locally Available Ingredients for Prevention of Nutrition Related Mental Illnesses. 

    Charles, Christina; Swai, Hulda; Msagati, Titus; Chacha, Musa (Taylor & Francis online, 2020-03-19)
    Poor mental health remains a serious public concern worldwide. The most vulnerable individuals are children and adolescents in developing countries. Nutritional deficiency of long-chain omega-3 fatty acids, particularly ...
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    Luteolin: a blocker of SARS-CoV-2 cell entry based on relaxed complex scheme, molecular dynamics simulation, and metadynamics 

    Shadrack, Daniel; Deogratias, Geradius; Kiruri, Lucy; Onoka, Isaac; Vianney, John-Mary; Swai, Hulda; Nyandoro, Stephen (Springer Nature, 2021-07-08)
    Natural products have served human life as medications for centuries. During the outbreak of COVID-19, a number of naturally derived compounds and extracts have been tested or used as potential remedies against COVID-19. ...
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    Ensemble-based screening of natural products and FDA-approved drugs identified potent inhibitors of SARS-CoV-2 that work with two distinct mechanisms 

    Shadrack, Daniel; Deogratias, Geradius; Kiruri, Lucy; Swai, Hulda; Vianney, John-Mary; Nyandoro, Stephen (Elsevier Ltd., 2021-06)
    The recent outbreak of SARS-CoV-2 is responsible for high morbidity and mortality rate across the globe. This requires an urgent identification of drugs and other interventions to overcome this pandemic. Computational ...
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    Solvent effects on host-guest residence time and kinetics: further insights from metadynamics simulation of Toussaintine-A unbiding from chitosan nanoparticle 

    Shadrack, Daniel M.; Kiruri, Lucy W.; Swai, Hulda; Nyandoro, Stephen S. (Springer Nature Switzerland AG., 2021-04-14)
    Solvents play an important role in host-guest intermolecular interactions. The kinetics and residence time of Toussaintine-A (TouA) unbinding from chitosan was investigated by means of well-tempered metadynamics and ...
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    Abrogating the nsp10–nsp16 switching mechanisms in SARS-CoV-2 by phytochemicals from Withania somnifera: a molecular dynamics study 

    Vuai, Said; Onoka, Isaac; Sahini, Mtabazi; Swai, Hulda; Shadrack, Daniel (Taylor & Francis Online, 2021-09-14)
    The search for therapeutic small molecules and vaccines for Covid-19 treatment is an urgent but evolving topic. The virus has claimed over 3,782,490 lives (as of 12 June 2021), with the figure expected to rise due to the ...
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    Ensemble-based screening of natural products and FDA-approved drugs identified potent inhibitors of SARS-CoV-2 that work with two distinct mechanisms 

    Shadrack, Daniel; Deogratias, Geradius; Kiruri, Lucy; Swai, Hulda; Vianney, John-Mary; Nyandoro, Stephen (Elsevier Inc., 2021-02-23)
    The recent outbreak of SARS-CoV-2 is responsible for high morbidity and mortality rate across the globe. This requires an urgent identification of drugs and other interventions to overcome this pandemic. Computational drug ...
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    Solvent effects on host-guest residence time and kinetics: further insights from metadynamics simulation of Toussaintine-A unbiding from chitosan nanoparticle 

    Shadrack, Daniel; Kiruri, Lucy; Swai, Hulda; Nyandoro, Stephen (Springer Nature, 2021-04-14)
    Solvents play an important role in host-guest intermolecular interactions. The kinetics and residence time of Toussaintine-A (TouA) unbinding from chitosan was investigated by means of well-tempered metadynamics and ...
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    Acute and sub-acute toxicity studies of chloroform extracts of cucumis metuliferus and lippia kituiensis in mice and rats model 

    Mzena, Theopista; Swai, Hulda; Chacha, Musa (World Journal of Pharmaceutical Research, 2020)
    Objective: To evaluate the acute and sub-acute oral toxicity of Cucumis metuliferus and Lippia kituiensis leaf chloroform extracts in mice and rats model. Methods: Acute oral toxicity study of chloroform extracts of L. ...
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    Development of a Natural Product Rich in Bioavailable Omega-3 DHA from Locally Available Ingredients for Prevention of Nutrition Related Mental Illnesses 

    Charles, Christina; Swai, Hulda; Msagati, Titus; Chacha, Musa (Taylor & Francis Online, 2020-03-19)
    Objectives: Poor mental health remains a serious public concern worldwide. The most vulnerable individuals are children and adolescents in developing countries. Nutritional deficiency of long-chain omega-3 fatty acids, ...
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    Antimalarial potential and phytochemical composition of fractions of Lippia kituiensis Vatke (Verbenaceae) growing in Northern Tanzania 

    Ng’etich, Japheth; Swai, Hulda; Njokah, Joseph; Wachira, Sabina; Koech, Lilian; Gathirwa, Jeremiah (Journal of Medicinal Plants Research, 2020-08-31)
    Despite past decades of steady advances in the fight against Malaria, statistics show that the disease is still a threat to human health. Previous successes in the development of antimalarial drugs from medicinal plants ...
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    Swai, Hulda (11)
    Shadrack, Daniel (6)Kiruri, Lucy (4)Nyandoro, Stephen (4)Chacha, Musa (3)Deogratias, Geradius (3)Onoka, Isaac (3)Vianney, John-Mary (3)Charles, Christina (2)Msagati, Titus (2)... View MoreSubjectCOVID-19 (5)Metadynamics (3)Natural products (3)SARS-CoV-2 (3)Docking screening (2)Free energy calculation (2)Locally available ingredients (2)MD simulation (2)Molecular dynamics (2)Nutrition related mental health (2)... View MoreDate Issued2021 (7)2020 (4)Has File(s)Yes (11)

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