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Genetic variants of CYP3A5, CYP2D6, SULT1A1, UGT2B15 and tamoxifen response in postmenopausal patients with breast cancer
(Springer Nature, 2007-01-23)
Introduction
Tamoxifen therapy reduces the risk of recurrence and prolongs the survival of oestrogen-receptor-positive patients with breast cancer. Even if most patients benefit from tamoxifen, many breast tumours either ...
Germination of Invasive Plant Seeds after Digestion by Horses in California
(Natural Areas Journal, 2008-10)
Using a unique sterile design intended to eliminate outside seed contamination of horse
feces, we investigated whether weed seeds germinate after digestion by horses. Feces were collected
from selected National Parks and ...
Mycobacterium bovis in rural Tanzania: Risk factors for infection in human and cattle populations
(Elsevier Ltd., 2007-01)
Although bovine tuberculosis is widespread throughout Africa, very little is known about risk factors for Mycobacterium bovis infection in either human or cattle populations. A human case–control study was conducted in ...
Modeling the proteome of a Marek's disease transformed cell line: a natural animal model for CD30 overexpressing lymphomas.
(Proteomics, 2007-04-18)
Marek's disease (MD) in the chicken, caused by the highly infectious MD alpha-herpesvirus (MDV), is both commercially important and a unique, naturally occurring model for human T-cell lymphomas overexpressing the Hodgkin's ...
CD14+ cells are required for IL-12 response in bovine blood mononuclear cells activated with Toll-like receptor (TLR) 7 and TLR8 ligands
(Elsevier, 2008)
Single-stranded viral RNA (ssRNA) was recently identified as the natural ligand for TLR7
and TLR8. ssRNA sequences from viruses, as well as their synthetic analogues stimulate
innate immune responses in immune cells from ...
The neoplastically transformed (CD30hi) Marek’s disease lymphoma cell phenotype most closely resembles T-regulatory cells
(Springer-Verlag, 2008-02-07)
Introduction Marek’s disease (MD), a herpesvirus-induced
lymphoma of chickens is a unique natural model of CD30-
overexpressing (CD30hi) lymphoma. We have previously
proposed that the CD30hi neoplastically transformed ...
Potential of treating tuberculosis with a polymeric nano-drug delivery system
(Elsevier, 2008-12-18)
An effective therapeutic regimen is available for the treatment of tuberculosis (TB), however in developing countries; patient non-compliance due to high dose frequency and the lengthy duration of treatment, presents a ...
Genotype-Dependent Tumor Regression in Marek’s Disease Mediated at the Level of Tumor Immunity
(Springer, 2008-03-18)
Marek’s disease (MD) of chickens is a unique
natural model of Hodgkin’s and Non Hodgkin’s lymphomas
in which the neoplastically-transformed cells over-express
CD30 (CD30hi) antigen. All chicken genotypes can be
infected ...
Local skin reaction (chancre) induced following inoculation of metacyclic trypanosomes in cattle by tsetse flies is dependent on CD4 T lymphocytes
(Blackwell Science Ltd, 2003)
The first visible response in livestock to the bite of a trypanosomeinfected
tsetse fly is the formation of a localized skin reaction,
also known as a chancre. This is an inflammatory response in
the skin associated ...
A polymeric system for the intra-oral delivery of an anti-fungal agent
(Elsevier Science Ltd., 2001)
Oral candidal infections are often persistent and intractable and thus the aim of this study was to develop a polymeric sustained
release device to improve the topical treatment of these infections. A self curing system ...