Browsing Life sciences and Bio-engineering by Author "Semete-Makokotlela, Boitumelo"
Now showing items 1-3 of 3
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In vivo/in vitro pharmacokinetic and pharmacodynamic study of spray-dried poly-(dl-lactic-co-glycolic) acid nanoparticles encapsulating rifampicin and isoniazid.
Booysen, Laetitia; Kalombo, Lonji; Brooks, Elizabeth; Hansen, Ryan; Gilliland, Janet; Gruppo, Veronica; Lungenhofer, Paul; Semete-Makokotlela, Boitumelo; Swai, Hulda; Kotzé, Awie; Lenaerts, Anne; du Plessis, Lissinda (Elsevier B.V., 2013-02-28)Poly-(dl-lactic-co-glycolic) acid (PLGA) nanoparticles were prepared by a double emulsion solvent evaporation spray-drying technique and coated with polyethylene glycol (PEG 1% v/v). The PLGA nanoparticles had a small size ... -
Mycolic acids, a promising mycobacterial ligand for targeting of nanoencapsulated drugs in tuberculosis
Lemmer, Yolandy; Kalombo, Lonji; Pietersen, Ray-Dean; Jones, Arwyn T.; Semete-Makokotlela, Boitumelo; Van Wyngaardt, Sandra; Ramalapa, Bathabile; Stoltz, Anton C.; Baker, Bienyameen; Verschoor, Jan A.; Swai, Hulda; de Chastellier, Chantal (Elsevier, 2015-06-06)The appearance of drug-resistant strains of Mycobacterium tuberculosis (Mtb) poses a great challenge to the development of novel treatment programmes to combat tuberculosis. Since innovative nanotechnologiesmight ... -
Spray-Dried, Nanoencapsulated, Multi-Drug Anti-Tuberculosis Therapy Aimed at OnceWeekly Administration for the Duration of Treatment
Kalombo, Lonji; Lemmer, Yolandy; Semete-Makokotlela, Boitumelo; Ramalapa, Bathabile; Nkuna, Patric; Booysen, Laetitia; Naidoo, Saloshnee; Hayeshi, Rose; Verschoor, Jan; Swai, Hulda (MDPI, 2019-08-15)Aiming to improve the treatment outcomes of current daily tuberculosis (TB) chemotherapy over several months, we investigated whether nanoencapsulation of existing drugs would allow decreasing the treatment frequency to ...