Browsing Life sciences and Bio-engineering by Author "Booysen, Laetitia"
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Effects of protein binding on the biodistribution of PEGylated PLGA nanoparticles post oral administration
Semete, Boitumelo; Booysen, Laetitia; Kalombo, Lonji; Ramalapa, Bathabile; Hayeshi, Rose; Swai, Hulda (Elsevier B.V., 2012-03-15)The surface of nanoparticles is often functionalised with polymeric surfactants, in order to increase systemic circulation time. This has been investigated mainly for intravenously administered nanoparticles. This study ... -
In vivo evaluation of the biodistribution and safety of PLGA nanoparticles as drug delivery systems
Semete, Boitumelo; Booysen, Laetitia; Lemmer, Yolandy; Kalombo, Lonji; Katata, Lebogang; Verschoor, Jan (Elsevier Inc., 2010-10)The remarkable physicochemical properties of particles in the nanometer range have been proven to address many challenges in the field of science. However, the possible toxic effects of these particles have raised some ... -
In vivo/in vitro pharmacokinetic and pharmacodynamic study of spray-dried poly-(dl-lactic-co-glycolic) acid nanoparticles encapsulating rifampicin and isoniazid.
Booysen, Laetitia; Kalombo, Lonji; Brooks, Elizabeth; Hansen, Ryan; Gilliland, Janet; Gruppo, Veronica; Lungenhofer, Paul; Semete-Makokotlela, Boitumelo; Swai, Hulda; Kotzé, Awie; Lenaerts, Anne; du Plessis, Lissinda (Elsevier B.V., 2013-02-28)Poly-(dl-lactic-co-glycolic) acid (PLGA) nanoparticles were prepared by a double emulsion solvent evaporation spray-drying technique and coated with polyethylene glycol (PEG 1% v/v). The PLGA nanoparticles had a small size ... -
Spray-Dried, Nanoencapsulated, Multi-Drug Anti-Tuberculosis Therapy Aimed at OnceWeekly Administration for the Duration of Treatment
Kalombo, Lonji; Lemmer, Yolandy; Semete-Makokotlela, Boitumelo; Ramalapa, Bathabile; Nkuna, Patric; Booysen, Laetitia; Naidoo, Saloshnee; Hayeshi, Rose; Verschoor, Jan; Swai, Hulda (MDPI, 2019-08-15)Aiming to improve the treatment outcomes of current daily tuberculosis (TB) chemotherapy over several months, we investigated whether nanoencapsulation of existing drugs would allow decreasing the treatment frequency to ...