Browsing Life sciences and Bio-engineering by Author "Swai, Hulda"
Now showing items 21-40 of 53
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In vitro antiproliferative potential of Annona senegalensis Pers. and Allophylus africanus P Beauv. plant extracts against selected cancer cell lines
Biseko, Emiliana Zacharia; Swai, Hulda; Mbugua, Regina Wachuka; Ndung’u, Jecinta Wanjiru; Chepng’etich, Jean; Gathirwa, Jeremiah (Journal of Medicinal Plants Research, 2019-07-10)The medicinal plants Annona senegalensis Pers. and Allophylus africanus P Beauv. are used in Tanzania traditional medicine for the treatment of cancer. However, there is no scientific documentation on their therapeutic ... -
In vitro antiproliferative potential of crude extracts from Carica papaya L. (Caricaceae) black seeds against prostate cancer cell lines'
Kateihwa, Benson; Swai, Hulda; Gathirwa, Jeremiah; Sauli, Elingarami (American Journals, 2022-04-30)Black seeds from papaya plants are utilized as traditional medicine in African and Asian cultures to improve the functioning of the male reproductive system and management of prostate cancer. This study analyzed the ... -
In vivo/in vitro pharmacokinetic and pharmacodynamic study of spray-dried poly-(dl-lactic-co-glycolic) acid nanoparticles encapsulating rifampicin and isoniazid.
Booysen, Laetitia; Kalombo, Lonji; Brooks, Elizabeth; Hansen, Ryan; Gilliland, Janet; Gruppo, Veronica; Lungenhofer, Paul; Semete-Makokotlela, Boitumelo; Swai, Hulda; Kotzé, Awie; Lenaerts, Anne; du Plessis, Lissinda (Elsevier B.V., 2013-02-28)Poly-(dl-lactic-co-glycolic) acid (PLGA) nanoparticles were prepared by a double emulsion solvent evaporation spray-drying technique and coated with polyethylene glycol (PEG 1% v/v). The PLGA nanoparticles had a small size ... -
Larvicidal activity of Hypoestes forskaolii (Vahl) R. Br root extracts against Anopheles gambiae Giless.s, Aedes aegypti L, and Culex quinquefasciatus Say
Sillo, Albert; Makirita, Winisia; Swai, Hulda; Chacha, Musa (Dove Press, 2019-04-26)Aim: This study aimed to evaluate larvicidal activity of Hypoestes forskaolii R. Br root extract against 3rd instar Anopheles gambiae, Aedes aegypti, and Culex quinquefasciatus. Methods: A protocol developed by the World ... -
Luteolin: a blocker of SARS-CoV-2 cell entry based on relaxed complex scheme, molecular dynamics simulation, and metadynamics
Shadrack, Daniel; Deogratias, Geradius; Kiruri, Lucy; Onoka, Isaac; Vianney, John-Mary; Swai, Hulda; Nyandoro, Stephen (Springer Nature, 2021-07-08)Natural products have served human life as medications for centuries. During the outbreak of COVID-19, a number of naturally derived compounds and extracts have been tested or used as potential remedies against COVID-19. ... -
Microalgae: An alternative natural source of bioavailable omega-3 DHA for promotion of mental health in East Africa
Charles, Christina; Msagati, Titus; Swai, Hulda; Chacha, Musa (Elsevier, 2019-10-11)Mental health illness associated with poor nutrition is a serious public concern worldwide. The most at risk individuals are children and adolescents in the developing world. Deficiencies in omega-3 DHA fatty acids have ... -
Mobile application development framework to support farming as a business via benchmarking: the case of Tanzania
Kyaruzi, John; Yonah, Zaipuna; Swai, Hulda (International Journal of Advanced Computer Research (IJACR), 2019-11)Contributions from various researchers and scholars have made major advances relevant to a wide range of mobile applications at various scales. Although current agricultural and rural development (ARD) systems have features ... -
Modifications of the hydrophilicity of heterocyclic methacrylate copolymers for protein release
Downesa, S.; Patel, M.; Di Silvio, L.; Swai, Hulda; Davy, K.; Braden, M. (Elsevier, 1995-12)A series of copolymers comprising ethyl methacrylate (EM) and tetrahydrofurfuryl methacrylate (THFMA) gelled with either THFMA monomer or hydroxyethyl methacrylate (HEMA) monomer have been developed. In this paper, we ... -
Mycolic acids, a promising mycobacterial ligand for targeting of nanoencapsulated drugs in tuberculosis
Lemmer, Yolandy; Kalombo, Lonji; Pietersen, Ray-Dean; Jones, Arwyn T.; Semete-Makokotlela, Boitumelo; Van Wyngaardt, Sandra; Ramalapa, Bathabile; Stoltz, Anton C.; Baker, Bienyameen; Verschoor, Jan A.; Swai, Hulda; de Chastellier, Chantal (Elsevier, 2015-06-06)The appearance of drug-resistant strains of Mycobacterium tuberculosis (Mtb) poses a great challenge to the development of novel treatment programmes to combat tuberculosis. Since innovative nanotechnologiesmight ... -
Nanoencapsulation of water-soluble drug, lamivudine, using a double emulsion spray-drying technique for improving HIV treatment
Tshweu, Lesego; Katata, Lebogang; Kalombo, Lonji; Swai, Hulda (Springer Nature Switzerland AG., 2013-10-22)Current treatments available for human immunodeficiency virus, namely antiretrovirals, do not completely eradicate the virus from the body, leading to life-time commitment. Many antiretrovirals suffer drawbacks from ... -
Nanomedicine: Past, present and future - A global perspective.
Chang, Esther; Harford, Joe; Eaton, Michael; Boisseau, Patrick; Dube, Admire; Hayeshi, Rose; Swai, Hulda; Lee, Dong (Elsevier Inc, 2015-12-18)Nanomedicine is an emerging and rapidly evolving field and includes the use of nanoparticles for diagnosis and therapy of a variety of diseases, as well as in regenerative medicine. In this mini-review, leaders in the field ... -
Optimized Preparation of Silver Nanoparticles from Polyethylene Glycol and Formaldehyde
Mlalila, Nichrous; Swai, Hulda; Hilonga, Askwar (International Research Journal of Pure & Applied Chemistry, 2016-12-19)The purpose of this work was to study the effect of various process and formulation parameters on size and shapes of silver nanoparticles (AgNPs) based on surface plasmon resonance (SPR). AgNPs were prepared by chemical ... -
Oral lipid-based nanoformulation of tafenoquine enhanced bioavailability and blood stage antimalarial efficacy and led to a reduction in human red blood cell loss in mice
Melariri, Paula; Kalombo, Lonji; Nkuna, Patric; Dube, Admire; Hayeshi, Rose; Ogutu, Benhards; Gibhard, Liezl; deKock, Carmen; Smith, Peter; Wiesner, Lubbe; Swai, Hulda (Dovepress, 2015-02-20): Tafenoquine (TQ), a new synthetic analog of primaquine, has relatively poor bioavailability and associated toxicity in glucose-6-phosphate dehydrogenase (G6PD)-deficient individuals. A microemulsion formulation of TQ ... -
Poly (D,L-lactide-co-glycolide) nanoparticles: Uptake by epithelial cells and cytotoxicity
Nkabinde, L. A.; Shoba-Zikhali, L. N. N.; Semete-Makokotlela, B.; Kalombo, L.; Swai, Hulda; Grobler, A.; Hamman, J. H. (eXPRESS Polymer Letters, 2014)Nanoparticles as drug delivery systems offer benefits such as protection of the encapsulated drug against degradation, site-specific targeting and prolonged blood circulation times. The aim of this study was to investigate ... -
Polyamidoamine Dendrimers for Enhanced Solubility of Small Molecules and Other Desirable Properties for Site Specific Delivery: Insights from Experimental and Computational Studies
Shadrack, Daniel M.; Swai, Hulda; Munissi, Joan J. E.; Mubofu, Egid B.; Nyandoro, Stephen S. (MDPI, 2018-06-12)Clinical applications of many small molecules are limited due to poor solubility and lack of controlled release besides lack of other desirable properties. Experimental and computational studies have reported on the ... -
A polymeric system for the intra-oral delivery of an anti-fungal agent
Patel, M.P.; Cruchley, A.T.; Coleman, D.C.; Swai, Hulda; Braden, M.; Williams, D.M. (Elsevier Science Ltd., 2001)Oral candidal infections are often persistent and intractable and thus the aim of this study was to develop a polymeric sustained release device to improve the topical treatment of these infections. A self curing system ... -
Potential of treating tuberculosis with a polymeric nano-drug delivery system
Swai, Hulda; Semete, B.; Kalombo, Lonji; Chelule, P. (Elsevier, 2008-12-18)An effective therapeutic regimen is available for the treatment of tuberculosis (TB), however in developing countries; patient non-compliance due to high dose frequency and the lengthy duration of treatment, presents a ... -
Preparation of rifampicin/lactose microparticle composites by a supercritical antisolvent-drug excipient mixing technique for inhalation delivery
Ober, Courtney A.; Kalombo, Lonji; Swai, Hulda; Gupta, Ram B. (Elsevier, 2013-02)Rifampicin (RIF) is precipitated in the presence of inhalable lactose particles using a supercritical antisolvent-drug excipient mixing (SAS-DEM) technique to create RIF/lactose microparticle composites intended to improve ... -
Preparation of rifampicin/poly(d,l-lactice) nanoparticles for sustained release by supercritical assisted atomization technique
Labuschagne, Philip; Adami, Renata; Liparoti, Sara; Naidoo, Saloshnee; Reverchon, E.; Swai, Hulda (Elsevier, 2014-11)In this work supercritical assisted atomization (SAA) process was used for the co-precipitation of poly(d,l-lactide) (PDLLA) and rifampicin (RIF) as nanoparticles for sustained release applications. The effect of the ... -
Preparation, characterization, and optimization of primaquine-loaded solid lipid nanoparticles
Omwoyo, Wesley; Ogutu, Bernhards; Oloo, Florence; Swai, Hulda; Kalombo, Lonji; Melariri, Paula; Mahanga, Geoffrey; Gathirwa, Jeremiah (Dovepress, 2014-08-11)Primaquine (PQ) is one of the most widely used antimalarial drugs and is the only available drug that combats the relapsing form of malaria. PQ use in higher doses is limited by severe tissue toxicity including hematological- ...