Browsing Life sciences and Bio-engineering by Author "Sauli, Elingarami"
Now showing items 1-20 of 35
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Biomonitoring of Acetylcholinesterase (AChE) Activity among Smallholder Horticultural Farmers Occupationally Exposed to Mixtures of Pesticides in Tanzania
Kapeleka, Jones; Sauli, Elingarami; Sadik, Omowunmi; Ndakidemi, Patrick (Hindawi, 2019-09-11)Biomonitoring of pesticides exposure has currently become a matter of great public concern due to the potential health effects of pesticides. ,is study assessed levels of acetylcholinesterase (AChE) inhibition and associated ... -
Blood cytokine responses to early secreted protein antigen-6/culture filtrate protein-10 tuberculosis antigens 2 months after antituberculosis treatment among patients with drug-susceptible pulmonary tuberculosis.
Mvungi, Happiness; Mbelele, Peter; Buza, Joram; Mpagama, Stellah; Sauli, Elingarami (Wolters Kluwer - Medknow, 2019-03-12)Background: Human tuberculosis is a chronic inflammatory disease caused by mycobacterium tuberculosis. Pulmonary tuberculosis is the result of the failure of host immune system to control mycobacterium tuberculosis. The ... -
Cardiovascular diseases in Tanzania: The burden of modifiable and intermediate risk factors
Roman, Wilfrida; Martin, Haikael; Sauli, Elingarami (AME Publishing Company, 2019-08-27)Abstract: Tanzania, like other developing countries, is facing a higher burden of cardiovascular diseases (CVDs). The country is experiencing rapid growth of modifiable and intermediate risk factors that accelerate CVD ... -
Causal relationship between Environmental Enteric Dysfunction (EED), poor WaSH practices and growth failure in children from Rukwa-Tanzania
Modern, Grantina; Mpolya, Emmanuel; Sauli, Elingarami (Elsevier, 2022-07)Stunting is the most prevalent form of chronic undernutrition. The Rukwa region in Tanzania has one of the highest prevalence of stunting, despite being one of the most food secure region in the country. It is therefore ... -
Changing Patterns and Drivers of Increased Pesticides Use in Smallholder Vegetable Production Systems in Tanzania
Kapeleka, Jones A.; Sauli, Elingarami; Sadik, Omowunmi; Ndakidemi, Patrick A. (BioRxiv, 2021-01-18)Pesticides use has become a key component of smallholder horticulture production. Therefore, dynamics in pesticides handling need to be ascertained. This study assessed drivers of pesticides use and determinants of changing ... -
Co-exposure risks of pesticides residues and bacterial contamination in fresh fruits and vegetables under smallholder horticultural production systems in Tanzania
Kapeleka, Jones; Sauli, Elingarami; Sadik, Omowunmi; Ndakidemi, Patrick (PLOS ONE, 2020-07-25)This study was carried out to investigate the risks of simultaneous exposure to pesticide residues and bacteria contaminants in locally produced fresh vegetables and vegetables in Tanzania. A total of 613 samples were ... -
Correlates of diarrhea and stunting among under-five children in Ruvuma, Tanzania; a hospital-based cross-sectional study
Modern, Grantina; Sauli, Elingarami; Mpolya, Emmanuel (Elsevier, 2020-07)Undernutrition affects 20% of children under five in the developing world. Stunting is a form of undernutrition when children have low height for their age. Global prevalence of stunting in 2019 was 21.4%, while current ... -
Development and Validation of a Mobile Game for Culturally Sensitive Child Sexual Abuse Prevention Education in Tanzania: Mixed Methods Study
Malamsha, Maria; Sauli, Elingarami; Luhanga, Edith (JMIR Publications Inc., Toronto, Canada, 2021-05-13)Background: Globally, 3 out of 20 children experience sexual abuse before the age of 18 years. Educating children about sexual abuse and prevention is an evidence-based strategy that is recommended for ending child sexual ... -
Digital Technologies to Enhance Infectious Disease Surveillance in Tanzania: A Scoping Review
Mustafa, Ummul-khair; Kreppel, Katharina; Brinkel, Johanna; Sauli, Elingarami (MDPI, 2023-02-06)Mobile phones and computer-based applications can speed up disease outbreak detection and control. Hence, it is not surprising that stakeholders in the health sector are becoming more interested in funding these technologies ... -
Expression analysis of p16 and TOP2A protein biomarkers in cervical cancer lesions and their correlation with clinico-histopathological characteristics in a referral hospital, Tanzania
Zuberi, Zavuga; Mremi, Alex; Chilongola, Jaffu; Semango, George; Sauli, Elingarami (PLOS ONE, 2021-10-27)Introduction Biomarkers yield important information for early diagnosis of cervical cancer. However, they are rarely applied for prognosis of cervical cancer in Tanzania, where visual inspection assay with acetic acid ... -
The extended scope of neuroimaging and prospects in brain atrophy mitigation: a systematic review
Sungura, Richard; Onyambu, Callen; Mpolya, Emmanuel; Sauli, Elingarami; Vianney, John-Mary (Elsevier B.V., 2020-08-15)Brain atrophy is a condition associated with a reduction of brain volume. It is a common manifestation of aging even though it occurs in some childhood conditions and carried forward to pre-senile middle age. There are ... -
Formulation, Optimization, and Evaluation of Moringa oleifera Leaf Polyphenol-Loaded Phytosome Delivery System against Breast Cancer Cell Lines
Wanjiru, Jecinta; Gathirwa, Jeremiah; Sauli, Elingarami; Swai, Hulda (MDPI, 2022-07-11)Moringa oleifera leaf polyphenols (Mopp) were encapsulated with phytosomes to enhance their efficacy on 4T1 cancer cell lines. The Mopp were extracted via microwave-assisted extraction. Moringa oleifera polyphenol-loaded ... -
Genetic variants of CYP3A5, CYP2D6, SULT1A1, UGT2B15 and tamoxifen response in postmenopausal patients with breast cancer
Wegman, Pia; Sauli, Elingarami; Carstensen, John; Stål, Olle; Wingren, Sten (Springer Nature, 2007-01-23)Introduction Tamoxifen therapy reduces the risk of recurrence and prolongs the survival of oestrogen-receptor-positive patients with breast cancer. Even if most patients benefit from tamoxifen, many breast tumours either ... -
Health professionals’ knowledge on dengue and health facility preparedness for case detection: A cross-sectional study in Dar es Salaam, TanzaniaHealth professionals’ knowledge on dengue and health facility preparedness for case detection: A cross-sectional study in Dar es Salaam, Tanzania
Mustafa, Ummul-khair; Sauli, Elingarami; Brinkel, Johanna; Kreppel, Katharina (PLOS, 2023-11-21)Dengue presents a growing public health concern in the Dar es Salaam region of Tanzania, marked by the recurring incidence of outbreaks. Unfortunately, there is little information available on the region’s preparedness in ... -
Impact of N-Acetyl Cysteine (NAC) on Tuberculosis (TB) Patients—A Systematic Review
Mapamba, Daniel; Sauli, Elingarami; Mrema, Lucy; Lalashowi, Julieth; Magombola, David; Buza, Joram; Olomi, Willyhelmina; Wallis, Robert; Ntinginya, Nyanda (MDPI, 2022-11-21)Sustained TB infection overproduces reactive oxygen species (ROS) as a host defense mechanism. Research shows ROS is destructive to lung tissue. Glutathione (GSH) neutralizes ROS, although it is consumed. NAC is a precursor ... -
In vitro antiproliferative potential of crude extracts from Carica papaya L. (Caricaceae) black seeds against prostate cancer cell lines'
Kateihwa, Benson; Swai, Hulda; Gathirwa, Jeremiah; Sauli, Elingarami (American Journals, 2022-04-30)Black seeds from papaya plants are utilized as traditional medicine in African and Asian cultures to improve the functioning of the male reproductive system and management of prostate cancer. This study analyzed the ... -
Insulin-delivery methods for children and adolescents with type 1 diabetes
Zuberi, Zavuga; Sauli, Elingarami; Cun, Liu; Deng, Jing; Li, Wen-Jun; He, Xu-Liang; Li, Wen (SAGE Publications Ltd., 2020-05-20)Efforts directed toward restoring normal metabolic levels by mimicking the physiological insulin secretion, thereby ensuring safety, efficacy, minimal invasiveness and conveniences, are of great significance in the ... -
Ki-67, p53 and BCL-2 Expressions and their Association with Clinical Histopathology of Breast Cancer among Women in Tanzania
Mansouri, Hidaya; Mnango, Leah; Magorosa, Erick; Sauli, Elingarami; Mpolya, Emmanuel (Scientific Reports, 2019-07-09)This study associated Ki-67, p53, and BCL-2 markers with clinical histopathological (CH) features using currently available limited data on these markers in Tanzania. Retrospective chart review study was conducted among ... -
Meta-narrative review of molecular methods for diagnosis and monitoring of multidrug-resistant tuberculosis treatment in adults
Mbelele, Peter; Mohamed, Sagal; Sauli, Elingarami; Mpolya, Emmanuel; Mfinanga, Sayoki; Addo, Kennedy; Heysell, Scott; Mpagama, Stellah (PubMed Central, 2019-06-04)Early and accurate diagnosis and rigorous clinical and microbiological monitoring of multidrug-resistant tuberculosis (MDR-TB) treatment can curb morbidity and mortality. While others are still under evaluation, the World ... -
Molecular Mechanism and Changes of Antioxidant Enzyme in ZnO Nanoparticles Against Fungus.
Zhang, Fengqin; Liu, Xiongduo; Pentok, Myima; Sauli, Elingarami; He, Nongyue; Zen, Xiangli; Li, Xiaolong; Liu, Tonghua (Ingenta Connect, 2020, 2019-04-01)Although zinc oxide nanoparticles are known as an effective antimicrobial agent, the mechanism for its antifungal activity has been assessed by only few studies. In this study, antifungal activity mechanism for ZnO via the ...