Antimicrobial activities of against selected pathogenic fungi and bacteria strains.

Abstract

and are dangerous pathogens causing fungal diseases. and developed resistance to fungicides such as fluconazole. Similarly, pathogenic bacteria have become resistant to antibiotcs such as methicillin. Thus, searching for alternative antimicrobial agents is inevitable. used traditionally for management of fungal and bacterial diseases is potential source of antimicrobial agents. It is in this vein that, antimicrobial activities of leaf and root extracts of were evaluated against (ATCC 90028), (clinical isolate), (ATCC25923), (ATCC29953), (ATCC 700603) and (NCTC 8385). A two-fold serial dilution method using the sterilised 96 wells of polystyrene microlitre plates used to determine the minimum inhibitory concentration (MIC) of extracts. Hexane and dichloromethane extracts exhibited the lowest activity against fungi strains with MICs >10 mg/mL. Root and leaf methanolic extracts exhibited activity at MICs of 5 and 1.25 mg/mL, respectively, against both tested fungi. Dichloromethane and methanolic extracts exhibited antibacterial activity with MICs ranging from 2.5 - 10 mg/mL and 0.625 - 5 mg/mL, respectively. Antimicrobial activities of the extracts of revealed potentiality of bioactives against fungal and bacterial diseases.