Estimating the risk of aflatoxin-induced liver cancer in Tanzania based on biomarker data.

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dc.contributor.author Kimanya, Martin E
dc.contributor.author Routledge, Michael N
dc.contributor.author Ezekiel, Chibundu N
dc.contributor.author Shirima, Candida P
dc.contributor.author Gong, Yun Yun
dc.contributor.author Mpolya, Emmanuel A.
dc.date.accessioned 2021-03-24T09:45:34Z
dc.date.available 2021-03-24T09:45:34Z
dc.date.issued 2021-03-11
dc.identifier.uri https://doi.org/10.1371/journal.pone.0247281
dc.identifier.uri https://dspace.nm-aist.ac.tz/handle/20.500.12479/1142
dc.description This research article published by PLOS ONE, 2021 en_US
dc.description.abstract Evidence about the magnitude of the aflatoxin menace can help policy makers appreciate the importance of the problem and strengthen policies to support aflatoxin mitigation measures. In this study, we estimated aflatoxin-induced liver cancer risk in 2016 for Tanzania and used the information to estimate the health burden due to the aflatoxin exposure in the country. The burden of aflatoxin-induced liver cancer was assessed based on available aflatoxin biomarker data from a previous epidemiology study, hepatitis B virus infection prevalence and population size of Tanzania in 2016. The health burden due to aflatoxin-induced liver cancer was estimated using disability adjusted life years (DALYs). The aflatoxin exposures ranged from 15.0-10,926.0 ng/kg bw/day (median, 105.5 ng/kg bw/day). We estimated that in 2016 there were about 1,480 (2.95 per 100,000 persons) new cases of aflatoxin-induced liver cancer in Tanzania and assumed all of them would die within a year. These morbidity and mortality rates led to a total loss of about 56,247.63 DALYs. These results show, quantitatively, the cases of liver cancer and related deaths that could be avoided, and the healthy life years that could be saved, annually, by strengthening measures to control aflatoxin contamination in Tanzania. en_US
dc.language.iso en en_US
dc.publisher PLOS ONE en_US
dc.subject Research Subject Categories::NATURAL SCIENCES en_US
dc.title Estimating the risk of aflatoxin-induced liver cancer in Tanzania based on biomarker data. en_US
dc.type Article en_US

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