Browsing by Author "Lalashowi, Julieth"
Now showing items 1-3 of 3
-
Impact of N-Acetyl Cysteine (NAC) on Tuberculosis (TB) Patients—A Systematic Review
Mapamba, Daniel; Sauli, Elingarami; Mrema, Lucy; Lalashowi, Julieth; Magombola, David; Buza, Joram; Olomi, Willyhelmina; Wallis, Robert; Ntinginya, Nyanda (MDPI, 2022-11-21)Sustained TB infection overproduces reactive oxygen species (ROS) as a host defense mechanism. Research shows ROS is destructive to lung tissue. Glutathione (GSH) neutralizes ROS, although it is consumed. NAC is a precursor ... -
N-acetylcysteine modulates markers of oxidation, inflammation and infection in tuberculosis
Mapamba, Daniel; Sabi, Issa; Lalashowi, Julieth; Sauli, Elingarami; Buza, Joram; Olomi, Willyhelmina; Mtafya, Bariki; Kibona, Michael; Velen, Kavindhran; Hoelscher, Michael (Elsevier, 2025-01-03)Background Half the global tuberculosis health burden is due to post-tuberculosis lung disease. Host-directed therapies have been proposed to reduce this burden. N-acetylcysteine (NAC) provides the conditionally essential ... -
Performance of Tuberculosis Molecular Bacterial Load Assay Compared to Alere TB-LAM in Urine of Pulmonary Tuberculosis Patients with HIV Co-Infections
Mapamba, Daniel; Sauli, Elingarami; Lalashowi, Julieth; Buza, Joram; John, Joseph; Mwaisango, Zawadi; Tarmo, Peter; Sabi, Issa; Rachow, Andrea; Ntinginya, Nyanda; Mtafya, Bariki (MDPI, 2023-02-23)Alternative tools are needed to improve the detection of M. tuberculosis (M. tb) in HIV co-infections. We evaluated the utility of Tuberculosis Molecular Bacterial Load Assay (TB-MBLA) compared to lipoarabinomannan (LAM) ...