The Significance of Stochastic CTMC Over Deterministic Model in Understanding the Dynamics of Lymphatic Filariasis With Asymptomatic Carriers
| dc.contributor.author | Stephano, Mussa | |
| dc.contributor.author | Irunde, Jacob | |
| dc.contributor.author | Mayengo, Maranya | |
| dc.contributor.author | Kuznetsov, Dmitry | |
| dc.date.accessioned | 2024-05-23T13:17:18Z | |
| dc.date.available | 2024-05-23T13:17:18Z | |
| dc.date.issued | 2024-05-04 | |
| dc.description | This research article was published by the Journals of Applied Mathematics ,Volume 2024, Article ID 2130429, | en_US |
| dc.description.abstract | Lymphatic filariasis is a leading cause of chronic and irreversible damage to human immunity. This paper presents deterministic and continuous-time Markov chain (CTMC) stochastic models regarding lymphatic filariasis dynamics. To account for randomness and uncertainties in dynamics, the CTMC model was formulated based on deterministic model possible events. A deterministic model’s outputs suggest that disease extinction is feasible when the secondary threshold infection number is below one, while persistence becomes likely when the opposite holds true. Furthermore, the significant contribution of asymptomatic carriers was identified. Results indicate that persistence is more likely to occur when the infection results from asymptomatic, acutely infected, or infectious mosquitoes. Consequently, the CTMC stochastic model is essential in capturing variabilities, randomness, associated probabilities, and validity across different scales, whereas oversimplification and unpredictability of inherent may not be featured in a deterministic model. | en_US |
| dc.identifier.govdoc | https://doi.org/10.1155/2024/2130429 | |
| dc.identifier.uri | https://doi.org/10.1155/2024/2130429 | |
| dc.identifier.uri | https://dspace.nm-aist.ac.tz/handle/20.500.12479/2663 | |
| dc.language.iso | en | en_US |
| dc.publisher | Hindawi | en_US |
| dc.subject | asymptomatic carriers; | en_US |
| dc.subject | CTMC stochastic model; | en_US |
| dc.subject | deterministic model; | en_US |
| dc.subject | lymphatic filariasis | en_US |
| dc.subject | multitype branching process | en_US |
| dc.title | The Significance of Stochastic CTMC Over Deterministic Model in Understanding the Dynamics of Lymphatic Filariasis With Asymptomatic Carriers | en_US |
| dc.type | Article | en_US |