Antimicrobial resistant enteric bacteria are widely distributed amongst people, animals and the environment in Tanzania.
| dc.contributor.author | Subbiah, Murugan | |
| dc.contributor.author | Caudell, Mark | |
| dc.contributor.author | Mair, Colette | |
| dc.contributor.author | Davis, Margaret | |
| dc.contributor.author | Matthews, Louise | |
| dc.contributor.author | Quinlan, Robert | |
| dc.contributor.author | Quinlan, Marsha | |
| dc.contributor.author | Lyimo, Beatus | |
| dc.contributor.author | Buza, Joram | |
| dc.contributor.author | Keyyu, Julius | |
| dc.contributor.author | Call, Douglas | |
| dc.date.accessioned | 2020-01-16T09:30:05Z | |
| dc.date.available | 2020-01-16T09:30:05Z | |
| dc.date.issued | 2020-01-13 | |
| dc.description | The research article published on Nature Communications 2020 | en_US |
| dc.description.abstract | Antibiotic use and bacterial transmission are responsible for the emergence, spread and persistence of antimicrobial-resistant (AR) bacteria, but their relative contribution likely differs across varying socio-economic, cultural, and ecological contexts. To better understand this interaction in a multi-cultural and resource-limited context, we examine the distribution of antimicrobial-resistant enteric bacteria from three ethnic groups in Tanzania. Household-level data (n = 425) was collected and bacteria isolated from people, livestock, dogs, wildlife and water sources (n = 62,376 isolates). The relative prevalence of different resistance phenotypes is similar across all sources. Multi-locus tandem repeat analysis (n = 719) and whole-genome sequencing (n = 816) of Escherichia coli demonstrate no evidence for host-population subdivision. Multivariate models show no evidence that veterinary antibiotic use increased the odds of detecting AR bacteria, whereas there is a strong association with livelihood factors related to bacterial transmission, demonstrating that to be effective, interventions need to accommodate different cultural practices and resource limitations. | en_US |
| dc.identifier.other | 31932601 | |
| dc.identifier.uri | https://doi.org/10.1038/s41467-019-13995-5 | |
| dc.identifier.uri | http://dspace.nm-aist.ac.tz/handle/123456789/527 | |
| dc.language.iso | en | en_US |
| dc.publisher | Nature Communications | en_US |
| dc.rights | Attribution-NonCommercial-ShareAlike 4.0 International | * |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | * |
| dc.subject | Antimicrobial resistance | en_US |
| dc.subject | Developing world | en_US |
| dc.subject | Epidemiology | en_US |
| dc.subject | Research Subject Categories::NATURAL SCIENCES | en_US |
| dc.title | Antimicrobial resistant enteric bacteria are widely distributed amongst people, animals and the environment in Tanzania. | en_US |
| dc.type | Article | en_US |