Show simple item record

dc.contributor.authorHerzog, Catherine
dc.contributor.authorde Glanville, William
dc.contributor.authorWillett, Brian
dc.contributor.authorCattadori, Isabella
dc.contributor.authorKapur, Vivek
dc.contributor.authorHudson, Peter
dc.contributor.authorSwai, Emmanuel
dc.contributor.authorCleaveland, Sarah
dc.contributor.authorBjørnstad, Ottar
dc.contributor.authorBuza, Joram
dc.date.accessioned2020-06-12T08:04:13Z
dc.date.available2020-06-12T08:04:13Z
dc.date.issued2020-02-07
dc.identifier.urihttps://doi.org/10.3390/v12020186
dc.identifier.urihttps://dspace.nm-aist.ac.tz/handle/20.500.12479/789
dc.descriptionThis research article published by MDPI, 2020en_US
dc.description.abstractPeste des petits ruminants virus (PPRV) causes a contagious disease of high morbidity and mortality in global sheep and goat populations. To better control this disease and inform eradication strategies, an improved understanding of how PPRV transmission risk varies by age is needed. Our study used a piece-wise catalytic model to estimate the age-specific force of infection (FOI, per capita infection rate of susceptible hosts) among sheep, goats, and cattle from a cross-sectional serosurvey dataset collected in 2016 in Tanzania. Apparent seroprevalence increased with age, reaching 53.6%, 46.8%, and 11.6% (true seroprevalence: 52.7%, 52.8%, 39.2%) for sheep, goats, and cattle, respectively. Seroprevalence was significantly higher among pastoral animals than agropastoral animals across all ages, with pastoral sheep and goat seroprevalence approaching 70% and 80%, respectively, suggesting pastoral endemicity. The best fitting piece-wise catalytic models merged age groups: two for sheep, three for goats, and four for cattle. The signal of these age heterogeneities were weak, except for a significant FOI peak among 2.5-3.5-year-old pastoral cattle. The subtle age-specific heterogeneities identified in this study suggest that targeting control efforts by age may not be as effective as targeting by other risk factors, such as production system type. Further research should investigate how specific husbandry practices affect PPRV transmission.en_US
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.subjectEpidemiologyen_US
dc.subjectCatalytic modelen_US
dc.subjectForce of infectionen_US
dc.subjectPeste-des-petits-ruminantsen_US
dc.subjectSeroepidemiologic studiesen_US
dc.titleIdentifying Age Cohorts Responsible for Peste Des Petits Ruminants Virus Transmission among Sheep, Goats, and Cattle in Northern Tanzania.en_US
dc.typeArticleen_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record