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dc.contributor.authorSeleman A., Mohamedi
dc.contributor.authorLuboobi S., Livingstone
dc.contributor.authorNkansah-Gyekye, Yaw
dc.date.accessioned2019-05-15T09:12:05Z
dc.date.available2019-05-15T09:12:05Z
dc.date.issued2017-08-25
dc.identifier.uriMathematical Sciences · August 2017 DOI: 10.20852/ntmsci.2017.196
dc.identifier.urihttp://dspace.nm-aist.ac.tz/handle/123456789/66
dc.descriptionResearch Article published by New Trends in Mathematical Sciencesen_US
dc.description.abstractIn this study, a mathematical model for the in-human host and in-mosquito dynamics of malaria parasite with immune responses was formualeted and analyzed. A positive invariant region of the model was established, and a basic reproduction number R0, of the model was computed. Existence and stability of two non-negative equilibrium points: malaria free equilibrium (MFE) and malaria infection equlibrium (MIE) were established. We, also proved that MFE is locally asymptotically stable if R0 < 1 and globally asymptotically stable (GAS) if R0 ≤ 1. Numerical simulations prove that MIE exists and is GAS. Moreover, our results revealed that immunity has significant influence on lowering malaria infection at blood and mosquito stages. However, an insignificant effect of immunity on both cells and parasites at liver stage infection was observed. Furthermore, the model depicts that infection decreases as lifespan of immune cells increases. The impact of immune cells to suppress production of merozoites is noted to be higher than that of antibodies to block invasion of sporozoites and merozoites.en_US
dc.language.isoen_USen_US
dc.publisherNew Trends in Mathematical Sciencesen_US
dc.subjectMalaria parasitesen_US
dc.subjectin-human host and in-mosquito dynamicsen_US
dc.subjectimmune responses.en_US
dc.titleThe in-Human Host and in-Mosquito Dynamics of Malaria Parasites With Immune Responsesen_US
dc.typeArticleen_US


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