| dc.description.abstract | The Nubian ibex (Capra nubiana) is a wild goat species that inhabits the Sahara and Arabian deserts and is adapted to extreme
ambient temperatures, intense solar radiation, and scarcity of food and water resources. To investigate desert adaptation,
we explored the possible role of copy number variations (CNVs) in the evolution of Capra species with a specifc focus on
the environment of Capra nubiana. CNVs are structural genomic variations that have been implicated in phenotypic dif ferences between species and could play a role in species adaptation. CNVs were inferred from Capra nubiana sequence
data relative to the domestic goat reference genome using read-depth approach. We identifed 191 CNVs overlapping with
protein-coding genes mainly involved in biological processes such as innate immune response, xenobiotic metabolisms,
and energy metabolisms. We found copy number variable genes involved in defense response to viral infections (Cluster of
Diferentiation 48, UL16 binding protein 3, Natural Killer Group 2D ligand 1-like, and Interferon-induced transmembrane
protein 3), possibly suggesting their roles in Nubian ibex adaptations to viral infections. Additionally, we found copy num ber variable xenobiotic metabolism genes (carboxylesterase 1, Cytochrome P450 2D6, Glutathione S-transferase Mu 4, and
UDP Glucuronosyltransferase-2B7), which are probably an adaptation of Nubian ibex to desert diets that are rich in plant
secondary metabolites. Collectively, this study’s results advance our understanding of CNVs and their possible roles in the
adaptation of Nubian ibex to its environment. The copy number variable genes identifed in Nubian ibex could be considered
as subjects for further functional characterizations. | en_US |
