The Efficacy of Single-Dose versus Double-Dose Praziquantel Treatments on Schistosoma mansoni Infections: Its Implication on Undernutrition and Anaemia among Primary Schoolchildren in Two On-Shore Communities, Northwestern Tanzania
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Date
2017-09-28
Authors
Munisi, David
Buza, Joram
Mpolya, Emanuel
Teckla, Angelo
Kinung’hi, Safari
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BioMed Research International
Abstract
Administeringmore than one treatmentmay increase Praziquantel cure and egg reduction rates, thereby hastening achievement of
schistosomiasis transmission control. A total of 431 S. mansoni-infected schoolchildren were randomized to receive either a single
or repeated 40mg/kg Praziquantel dose. Heights, weights, and haemoglobin levels were determined using a stadiometer, weighing
scale, and HemoCue, respectively. At 8 weeks, cure rate was higher on repeated dose (93.10%) compared to single dose (68.68%)
(𝑝 < 0.001).Theegg reduction rate was higher on repeated dose (97.54%) compared to single dose (87.27%) (𝑝 = 0.0062).Geometric
mean egg intensity was lower among those on repeated dose (1.30 epg) compared to single dose (3.18 epg) (𝑝 = 0.036) but not at 5
(𝑝 > 0.05) and 8 (𝑝 > 0.05) months with no difference in reinfection rate. No difference in the prevalence of stunting was observed
between the two treatment regimens (𝑝 > 0.05) at 8 months, but there was an increase in the prevalence of wasting among those on
repeated dose (𝑝 < 0.001). There was an increase in the mean haemoglobin levels at 8 months with no difference between the two
arms (𝑝 > 0.05). To achieve reduction of transmission intensity and disease control in highly endemic areas, repeated treatments
alone may not be sufficient.This trial was registered with PACTR201601001416338.
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