Browsing by Author "Olukayode, Odufuwa"

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    Fabric integrity, net type and risk index predicts attrition of insecticide-treated nets: evidence from a community durability trial of piperonyl butoxide (PBO) nets in Tanzania
    (Malaria Journal, 2025-11-26) Mvungi, Nolvin; Olukayode, Odufuwa; Ruzige, Philipo; Muganga, Joseph; Mmasi, Dorin; Machange, Jane; Kamande, Dismas; Madumla,Edith; Moore, Jason; Mwema, Mwema; Moore, Sarah; Mbuba, Emmanuel
    The fabric integrity of insecticide-treated nets (ITNs) deteriorates over time during household use, often leading households to discard or stop using damaged nets. This study quantified the extent to which net loss from households is attributable to declining fabric integrity, accounting for variation in user behaviour and environmental conditions. Methods This secondary analysis used data from an ITN durability trial in Bagamoyo, Tanzania. A total of 2,514 ITNs (three pyrethroid-PBO and one pyrethroid-only) distributed among 1,509 households were included because they had the outcome of interest (attrition). Fabric integrity was classified as good, damaged, or too-torn according to WHO ITN guidelines and assessed at 12-month intervals. The association between fabric integrity and net attrition over the subsequent 12 months was evaluated using an adjusted logistic regression model, accounting for net type, household risk index, household size, and age of the household head as fixed effects, with household as a random effect. Results Attrition increased over time, from 20% at one year to 53% at two years, and 83% at three years post-distribution, and it was associated with net type, household risk index, household size, and age of the household head. Damaged ITNs at one year were more likely to be lost by year two. Compared to nets in good condition, damaged nets had higher odds of attrition (OR: 1.73, 95% CI: 1.06-2.82), and too-torn nets were at greater risk (OR: 9.82, 95% CI: 5.87-16.4). Similar patterns were observed between years two and three (damaged: OR =1.55, 95% CI: 0.83-2.90; too- torn: OR=11.7, 95% CI: 6.16-22.3).ACCEPTED MANUSCRIPTARTICLE IN PRESS ARTICLE IN PRESSConclusion Fabric integrity was the main driver of rapid ITN attrition and the strongest predictor of loss. Damaged nets were approximately twice as likely to be discarded after one year and at least ten times more likely to be lost in years two and three. These findings highlight the importance of promoting proper net care practices and procuring durable nets that withstand harsh household conditions, ensuring sustained population coverage.
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    Laboratory efficacy of Bactivec ® and Griselesf ® biolarvicides used for large-scale larviciding in Tanzania
    (Frontiers, 2025-07-21) Tegemeo, Gavana; Kailembo, Denis; Machange, Jane; Venance Michael; Swai, Kyeba; Olukayode, Odufuwa; Tenywa, Frank; Mwalimu, Charles; Jubilate Bernard; Samwel Lazaro; Best Yoram; Kajange, Stella; Kasagama, Elizabeth; Kisoka, Noela; Mbuba, Emmanuel; Chaki, Prosper; Lengeler, Christian; Moore, Sarah
    From 2022 to 2024, a project piloting large-scale larviciding in Tanzania was implemented in Tanga Region. The project used in-country manufactured biolarvicides, The study was conducted at Ifakara Health Institute (IHI) in Tanzania. Laboratory-based dose–response experiments were performed using Bactivec® and Griselesf® against laboratory-reared early third instar larvae of Anopheles gambiae sensu stricto, Anopheles arabiensis, Anopheles funestus, Aedes aegypti and Culex quinquefasciatus. Larvae were exposed to various concentrations of Bactivec® and Griselesf®. VectoBac® served as a positive control, and distilled water as a negative control. Twelve replicates per concentration, with 25 larvae per replicate, were tested. Larval mortality was recorded at 24 and 48 hours after exposure to Bactivec® and Griselesf®, respectively. Probit regression analysis was used to determine the lethal concentration (LC50 and LC90) values.Bactivec® and Griselesf®. This study independently assessed the efficacy of both biolarvicide products to ensure that they represented a good option for scaling up.