Browsing by Author "Mansouri, Hidaya"

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Association of Ki-67, p53 and BCL-2 bio-markers expression with Clinic-Histopathology of breast cancer among women in Tanzania
(NM-AIST, 2019-07) Mansouri, Hidaya
Ki-67, p53, and BCL-2 are now emerging as markers for classifying breast cancer, guiding therapy and predicting treatment responses and prognosis. Restricted data currently exist on these molecular markers in Tanzania; hence, we assessed the expressions of Ki-67, p53, and BCL-2 and associated them with clinical histopathological features in breast cancer patients attending Muhimbili referral hospital in Tanzania. This retrospective cross-sectional hospitalbased study was carried out between 2016 and 2017. For this research, only women were chosen with proven breast cancer, complete clinical history and accessible paraffin block samples. Tissue samples were immunohistochemically stained for Ki-67, p53, and BCL-2, with respect to their specific Monoclonal Mouse Anti-Human. The relationship between Ki67, p53 and BCL-2 expressions and clinical histopathological features was determined using a multinomial linear regression model. Only 76 cases met the inclusion criteria for this study, with a mean age of 51.32 ±14.28 years. Of these, 86.4% were stage III and IV, whereas 83.5% cases had grade 2 and grade 3. Upon immunostaining, 85.5% and 57.9% were Ki-67 and BCL-2 positive, respectively. Log-linear analysis showed no statistically significant association among biomarkers expression and CH features. However, multinomial linear regression showed higher possibility for association between Ki-67+, p53- and BCL-2+ with age, grade, stage and tumor (T) stage. BCL-2 was positively correlated with Ki-67 expression contrary to p53, which was negatively correlated with BCL-2. Conclusively, there is evidence of correlation between the studied markers with CH features making these markers potential tools for evaluating treatment response in individualized therapeutic schemes.
Ki-67, p53 and BCL-2 Expressions and their Association with Clinical Histopathology of Breast Cancer among Women in Tanzania
(Scientific Reports, 2019-07-09) Mansouri, Hidaya; Mnango, Leah; Magorosa, Erick; Sauli, Elingarami; Mpolya, Emmanuel
This study associated Ki-67, p53, and BCL-2 markers with clinical histopathological (CH) features using currently available limited data on these markers in Tanzania. Retrospective chart review study was conducted among females with confrmed breast cancer (BC) at Muhimbili National Hospital in Tanzania between 2016 and 2017. Inclusion criteria were met by 76 patients with a mean age of 51.32±14.28 years. Of these, 86.4% were stage III and IV, whereas 83.5% cases had grade 2 and grade 3. Upon immunostaining, 85.5% and 57.9% were Ki-67 and BCL-2 positive respectively. Log-linear analysis showed no statistically signifcant association among biomarkers expression and CH features. However, multinomial linear regression showed higher possibility for association between high expression of Ki-67, low expression of p53 and high expression of BCL-2 with age, grade, stage and tumor (T) stage. BCL-2 was positively correlated with Ki-67 expression contrary to p53, which was negatively correlated with BCL-2. Conclusively, there is evidence of correlation between the studied markers with CH features. However, studies with larger sample sizes will likely reveal signifcant associations that will validate the role of these markers as tools for evaluating treatment response in individualized therapeutic schemes in Tanzania.
A Review on the Status of Breast Cancer Care in Tanzania
(Multidisciplinary Cancer Investigation, 2020-07-01) Mansouri, Hidaya; Mwakigonja, Amos R.; Rodgers, Faith A.; Mpolya, Emmanuel; Sauli, Elingarami
Tanzania continues to enjoy stability and growth in different sectors similar to other countries; however, some challenges persist in the health sector, especially in the area of cancer care. The current study aimed at reviewing social economic status (SES), as well as factors contributing to the increased burden of breast cancer (BC) in Tanzania. The current study reviewed different literature ranging from nationally/ internationally published statistics, academic publications, health information of non-governmental organizations, academic researchers, and other sources of health information to better understand the socioeconomic and BC care status in Tanzania. The current review showed that BC is still the second most prevalent malignant disease in Tanzania, and most of the patients referring to medical centers are in the advanced stage of the disease due to shortage and unaffordability of health care services. The majority of health-related interventions and investments target infectious diseases, including HIV-AIDS, tuberculosis, malaria, as well as maternal and child health-related conditions, compared to noncommunicable diseases (NCDs) such as BC. In spite of some setbacks and improvements in healthcare facilities (e g, novel techniques for early detection), the best way to address BC care is affordable fees for clinical and laboratory investigations, accessible treatment, palliative care, follow-up, rehabilitative care, and better management and allocation of resources.