Browsing by Author "Innes, Elisabeth"

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    Livestock abortion surveillance in Tanzania reveals disease priorities and importance of timely collection of vaginal swab samples for attribution
    (eLife Sciences Publications Limited, 2024-12-16) Lankester, Felix; Kibona, Tito; Allan, Kathryn; Glanville, William; Buza, Joram; Katzer, Frank; Mmbaga, Blandina; Wheelhouse, Nick; Innes, Elisabeth; Thomas, Kate; Nyasebwa, Obed; Swai, Emanuel; Claxton, John; Cleaveland, Sarah
    Lack of data on the aetiology of livestock diseases constrains effective interventions to improve livelihoods, food security and public health. Livestock abortion is an important disease syndrome affecting productivity and public health. Several pathogens are associated with livestock abortions but across Africa surveillance data rarely include information from abortions, little is known about aetiology and impacts, and data are not available to inform interventions. This paper describes outcomes from a surveillance platform established in Tanzania spanning pastoral, agropastoral and smallholder systems to investigate causes and impacts of livestock abortion. Abortion events were reported by farmers to livestock field officers (LFO) and on to investigation teams. Events were included if the research team or LFO could attend within 72 hr. If so, samples and questionnaire data were collected to investigate (a) determinants of attribution; (b) patterns of events, including species and breed, previous abortion history, and seasonality; (c) determinants of reporting, investigation and attribution; (d) cases involving zoonotic pathogens. Between 2017–2019, 215 events in cattle (n=71), sheep (n=44), and goats (n=100) were investigated. Attribution, achieved for 19.5% of cases, was significantly affected by delays in obtaining samples. Histopathology proved less useful than PCR due to rapid deterioration of samples. Vaginal swabs provided practical and sensitive material for pathogen detection. Livestock abortion surveillance, even at a small scale, can generate valuable information on causes of disease outbreaks, reproductive losses and can identify pathogens not easily captured through other forms of livestock disease surveillance. This study demonstrated the feasibility of establishing a surveillance system, achieved through engagement of community-based field officers, establishment of practical sample collection and application of molecular diagnostic platforms.
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    Prospective cohort study reveals unexpected aetiologies of livestock abortion in northern Tanzania
    (Springer Nature Limited, 2022-07-08) Thomas, Kate; Kibona, Tito; Claxton, John; de Glanville, William; Lankester, Felix; Amani, Nelson; Buza, Joram; Carter, Ryan; Chapman, Gail; Crump, John; Dagleish, Mark; Halliday, Jo; Hamilton, Clare; Innes, Elisabeth; Katzer, Frank; Livingstone, Morag; Longbottom, David; Millins, Caroline; Mmbaga, Blandina; Mosha, Victor; Nyarobi, James; Nyasebwa, Obed; Russell, George; Sanka, Paul; Semango, George; Wheelhouse, Nick; Willett, Brian; Cleaveland, Sarah; Allan, Kathryn
    Livestock abortion is an important cause of productivity losses worldwide and many infectious causes of abortion are zoonotic pathogens that impact on human health. Little is known about the relative importance of infectious causes of livestock abortion in Africa, including in subsistence farming communities that are critically dependent on livestock for food, income, and wellbeing. We conducted a prospective cohort study of livestock abortion, supported by cross-sectional serosurveillance, to determine aetiologies of livestock abortions in livestock in Tanzania. This approach generated several important findings including detection of a Rift Valley fever virus outbreak in cattle; high prevalence of C. burnetii infection in livestock; and the first report of Neospora caninum, Toxoplasma gondii, and pestiviruses associated with livestock abortion in Tanzania. Our approach provides a model for abortion surveillance in resource-limited settings. Our findings add substantially to current knowledge in sub-Saharan Africa, providing important evidence from which to prioritise disease interventions.