Meta-analysis on the entomological effects of differentially treated ITNs in a multi-site experimental hut study in sub-Saharan Africa

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dc.contributor.authorLissenden, Natalie
dc.contributor.authorBradley, John
dc.contributor.authorMenze, Benjamin
dc.contributor.authorWondji, Charles
dc.contributor.authorEdi, Constant
dc.contributor.authorKoudou, Benjamin
dc.contributor.authorN’Guessan, Raphael
dc.contributor.authorBayili, Koama
dc.contributor.authorDiabaté, Abdoulaye
dc.contributor.authorMbewe, Njelembo
dc.contributor.authorEmidi, Basiliana
dc.contributor.authorMosha, Jacklin
dc.contributor.authorManjurano, Alphaxard
dc.contributor.authorSmall, Graham
dc.contributor.authorOumbouke, Welbeck
dc.contributor.authorMoore, Sarah
dc.contributor.authorNimmo, Derric
dc.contributor.authorSnetselaar, Janneke
dc.date.accessioned2025-09-27T06:41:40Z
dc.date.issued2025-02-04
dc.descriptionSDG-3: Good Health and Well-being
dc.description.abstractBackground Restricting the placement of active ingredients (AIs) to specific panels on insecticide-treated nets (ITNs) has the potential to reduce the amount of AI required to treat a net. If the restricted placement of the AIs can exploit mosquito behaviour, particularly where they interact with the bed net interface, and not impact the net’s effectiveness, then the reduction in AI could result in cost reductions. Methods Nine individual experimental hut trials were conducted to compare the efficacy of three different partially-treated net relative to fully treated nets; roof-only treated nets, side-only treated nets, and nets with treated roof and pyrethroid-only side panels. These trials were conducted on a range of net products with different AIs, across a range of geographies in Africa (East and West), vector species (Anopheles gambiae, Anopheles coluzzii, Anopheles arabiensis, and Anopheles funestus), hut designs (East and West African style) and hosts (cows and humans). The combined data from these trials were analysed in a meta-analysis, and odds ratios for the effect of the different net designs on mortality and blood-feeding were estimated using mixed effects logistic regression. Results The results of this meta-analysis demonstrated that fully treated nets provide greater mosquito killing and reduction in blood-feeding effects than any configuration of insecticide treatment restricted to specific panels. Conclusions This meta-analysis showed that partially-treated net that restrict the insecticide treatment to specific panels of an ITN do not give equivalency or superiority in either mortality or blood-feeding inhibition to fully treated nets. The implications of these findings are discussed.
dc.identifier.urihttps://doi.org/10.1186/s12936-025-05264-2
dc.identifier.urihttps://dspace.nm-aist.ac.tz/handle/123456789/3329
dc.language.isoen
dc.publisherBMC
dc.subjectMalaria
dc.subjectMosquito
dc.subjectAnopheles
dc.subjectExperimental hut study
dc.subjectInsecticide-treated net
dc.subjectHybrid net
dc.subjectPartially-treated net
dc.titleMeta-analysis on the entomological effects of differentially treated ITNs in a multi-site experimental hut study in sub-Saharan Africa
dc.typeArticle

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