Browsing Research Articles [LISBE] by Author "Ogutu, Bernhards"
Now showing items 1-2 of 2
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Development, characterization and antimalarial efficacy of dihydroartemisinin loaded solid lipid nanoparticles.
Omwoyo, Wesley; Melariri, Paula; Gathirwa, Jeremiah; Oloo, Florence; Mahanga, Geoffrey; Kalombo, Lonji; Ogutu, Bernhards; Swai, Hulda (Elsevier, 2016-04-01)Effective use of dihydroartemisinin (DHA) is limited by poor water-solubility, poor pharmacokinetic profile and unsatisfactory clinical outcome especially in monotherapy. To reduce such limitations, we reformulated DHA ... -
Preparation, characterization, and optimization of primaquine-loaded solid lipid nanoparticles
Omwoyo, Wesley; Ogutu, Bernhards; Oloo, Florence; Swai, Hulda; Kalombo, Lonji; Melariri, Paula; Mahanga, Geoffrey; Gathirwa, Jeremiah (Dovepress, 2014-08-11)Primaquine (PQ) is one of the most widely used antimalarial drugs and is the only available drug that combats the relapsing form of malaria. PQ use in higher doses is limited by severe tissue toxicity including hematological- ...