Effects of spray-drying on w/o/w multiple emulsions prepared from a stearic acid matrix

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dc.contributor.author Mlalila, Nichrous
dc.contributor.author Swai, Hulda Shaidi
dc.contributor.author Kalombo, Lonji
dc.contributor.author Hilonga, Askwar
dc.date.accessioned 2019-05-17T12:55:47Z
dc.date.available 2019-05-17T12:55:47Z
dc.date.issued 2014-01-01
dc.identifier.uri http://dspace.nm-aist.ac.tz/handle/123456789/77
dc.description Research Article published by Devo Press Journal en_US
dc.description.abstract The goal of this study was to explore the effects of spray-drying on w/o/w double emulsions of methyltestosterone (MT) loaded in a stearic acid matrix. MT-loaded nanoparticles were formulated by a water-in-oil-in-water emulsion technique using 50, 75, and 100 mg of stearic acid, 2% and 3% w/v polyvinyl alcohol, 5% w/v lactose, and 0.2% w/v chitosan. The emulsions were immediately spray-dried based on an optimized model of inlet temperature and pump rate, and characterized for optimized responses with regard to particle size, polydispersity index, and zeta potential, for both emulsion and powder samples. Dynamic light scattering analysis shown that the nanoparticles increased in size with increasing concentrations of polyvinyl alcohol and stearic acid. Scanning electron microscopy indicated that the MT-loaded nanoparticles were spherical in shape, had a smooth surface, and were in an amorphous state, which was confirmed by differential scanning calorimetry. These MT-loaded nanoparticles are a promising candidate carrier for the delivery of MT; however, further studies are needed in order to establish the stability of the system and the cargo release profile under normal conditions of use. en_US
dc.language.iso en_US en_US
dc.subject double emulsions en_US
dc.subject spray-drying en_US
dc.subject nanoparticles en_US
dc.title Effects of spray-drying on w/o/w multiple emulsions prepared from a stearic acid matrix en_US
dc.type Article en_US

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