Pesticide exposure and genotoxic effects as measured by DNA damage and human monitoring biomarkers.

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dc.contributor.author Kapeleka, Jones A
dc.contributor.author Sauli, Elingarami
dc.contributor.author Ndakidemi, Patrick A.
dc.date.accessioned 2020-03-04T11:10:18Z
dc.date.available 2020-03-04T11:10:18Z
dc.date.issued 2019-11-18
dc.identifier.other 31736325
dc.identifier.uri https://doi.org/10.1080/09603123.2019.1690132
dc.identifier.uri http://dspace.nm-aist.ac.tz/handle/123456789/597
dc.description This research article published by Taylor & Francis Online, 2019 en_US
dc.description.abstract Occupational pesticides exposure rises health concern due to genotoxicity and accumulation of pesticides in human biological matrices. Continuous and sublethal exposure to pesticides had been associated with oxidative stress, mutagenic and cell death. Exposure to pesticides exhibits increased level of DNA damage even if no detectable amounts of pesticides are seen in biological matrices by binding specific areas in the DNA. This interferes normal body systems and mutation in gene encoding specific activities which may lead to a wide range of cancer. Presence of pesticides compounds in human biological matrices had been evident from various studies. However, detection methods are complex and inconsistent, making it difficult to compare and generalize findings. This article provides insight into genotoxic effects, presence of pesticides and their metabolites in human biological matrices and the resultant health effects as measured by DNA damage, acetylcholinesterase (AChE) activity inhibition and other biomarkers of pesticides exposure. en_US
dc.language.iso en en_US
dc.publisher Taylor & Francis online en_US
dc.subject Acetylcholinesterase (AChE) en_US
dc.subject occupational exposure en_US
dc.subject oxidative stress en_US
dc.subject smallholder farmers en_US
dc.title Pesticide exposure and genotoxic effects as measured by DNA damage and human monitoring biomarkers. en_US
dc.type Article en_US

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