Antimicrobial resistant enteric bacteria are widely distributed amongst people, animals and the environment in Tanzania.

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dc.contributor.author Subbiah, Murugan
dc.contributor.author Caudell, Mark A
dc.contributor.author Mair, Colette
dc.contributor.author Davis, Margaret A
dc.contributor.author Matthews, Louise
dc.contributor.author Quinlan, Robert J
dc.contributor.author Quinlan, Marsha B
dc.contributor.author Lyimo, Beatus
dc.contributor.author Buza, Joram J.
dc.contributor.author Keyyu, Julius
dc.contributor.author Call, Douglas R
dc.date.accessioned 2020-01-16T09:30:05Z
dc.date.available 2020-01-16T09:30:05Z
dc.date.issued 2020-01-13
dc.identifier.other 31932601
dc.identifier.uri https://doi.org/10.1038/s41467-019-13995-5
dc.identifier.uri http://dspace.nm-aist.ac.tz/handle/123456789/527
dc.description The research article published on Nature Communications 2020 en_US
dc.description.abstract Antibiotic use and bacterial transmission are responsible for the emergence, spread and persistence of antimicrobial-resistant (AR) bacteria, but their relative contribution likely differs across varying socio-economic, cultural, and ecological contexts. To better understand this interaction in a multi-cultural and resource-limited context, we examine the distribution of antimicrobial-resistant enteric bacteria from three ethnic groups in Tanzania. Household-level data (n = 425) was collected and bacteria isolated from people, livestock, dogs, wildlife and water sources (n = 62,376 isolates). The relative prevalence of different resistance phenotypes is similar across all sources. Multi-locus tandem repeat analysis (n = 719) and whole-genome sequencing (n = 816) of Escherichia coli demonstrate no evidence for host-population subdivision. Multivariate models show no evidence that veterinary antibiotic use increased the odds of detecting AR bacteria, whereas there is a strong association with livelihood factors related to bacterial transmission, demonstrating that to be effective, interventions need to accommodate different cultural practices and resource limitations. en_US
dc.language.iso en en_US
dc.publisher Nature Communications en_US
dc.rights Attribution-NonCommercial-ShareAlike 4.0 International *
dc.rights.uri http://creativecommons.org/licenses/by-nc-sa/4.0/ *
dc.subject Antimicrobial resistance en_US
dc.subject Developing world en_US
dc.subject Epidemiology en_US
dc.subject Research Subject Categories::NATURAL SCIENCES en_US
dc.title Antimicrobial resistant enteric bacteria are widely distributed amongst people, animals and the environment in Tanzania. en_US
dc.type Article en_US

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