Antimalarial activity of Cucumis metuliferus and Lippia kituiensis against Plasmodium berghei infection in mice

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dc.contributor.author Mzena, Theopista
dc.contributor.author Swai, Hulda S.
dc.contributor.author Chacha, Musa
dc.date.accessioned 2019-10-18T11:18:23Z
dc.date.available 2019-10-18T11:18:23Z
dc.date.issued 2018
dc.identifier.uri http://dx.doi.org/10.2147/RRTM.S150091
dc.identifier.uri http://dspace.nm-aist.ac.tz/handle/123456789/510
dc.description Research Article published by Dovepress en_US
dc.description.abstract Background: The search for new antimalarial drugs has become progressively urgent due to plasmodial resistance to most of the commercially available antimalarial drugs. As part of this effort, the study evaluated the antimalarial activity of Cucumis metuliferus and Lippia kituiensis, which are traditionally used in Tanzania for the treatment of malaria. Materials and methods: In vivo antimalarial activity was assessed using the 4-day suppressive antimalarial assay. Mice were infected by injecting via tail vein 1×107 erythrocytes infected by Plasmodium berghei ANKA. Extracts were administered orally; chloroquine (10 mg/kg/day) and dimethyl sulfoxide (5 mL/kg/day) were used as positive and negative controls, respectively. The level of parasitemia, survival time, packed cell volume (PCV) and variation in body weight of mice were used to determine the antimalarial activity of the extract. Results: The ethyl acetate, methanolic and chloroform extracts of C. metuliferus and L. kituiensis significantly (p<0.05) inhibited parasitemia in a dose-dependent manner and prevented loss of body weight at the dose levels of 600 mg/kg and 1500 mg/kg, respectively. In addition, the extracts prolonged the mean survival time of P. berghei-infected mice compared to the non-treated control. The plant extracts did not show reduction of PCV except at the low dose of 300 mg/kg. The highest suppression was recorded at the dose level of 1,500 mg/kg. At this dose, C. metuliferus in chloroform, methanolic and ethyl acetate extracts had percentage suppression of 98.55%, 88.89% and 84.39%, respectively, whereas L. kituiensis in ethyl acetate, chloroform and methanolic extracts exhibited suppression of the pathogens of 95.19%, 93.88% and 74.83%, respectively. Conclusion: It is worth reporting that the two plants induced suppression which is equivalent to that induced by chloroquine (C. metuliferus chloroform and L. Kituiensis ethyl acetate). The two plants have been demonstrated to be potential sources of antimalarial templates. en_US
dc.language.iso en en_US
dc.publisher Dovepress en_US
dc.subject Cucumis metuliferus en_US
dc.subject Lippia kituiensis en_US
dc.subject Plasmodium berghei en_US
dc.subject crude extracts en_US
dc.title Antimalarial activity of Cucumis metuliferus and Lippia kituiensis against Plasmodium berghei infection in mice en_US
dc.type Article en_US

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