Colorectal cancer epidemiology in Tanzania: patterns in relation to dietary and lifestyle factors

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dc.contributor.author Kamanga, Leonard
dc.date.accessioned 2019-06-04T09:17:55Z
dc.date.available 2019-06-04T09:17:55Z
dc.date.issued 2019-01
dc.identifier.uri http://dspace.nm-aist.ac.tz/handle/123456789/295
dc.description A Dissertation Submitted in Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy in Life Sciences and Bio-Engineering of the Nelson Mandela African Institution of Science and Technology en_US
dc.description.abstract Chronic non-communicable diseases are increasingly captured as contributing to morbidity and mortality in low and middle income countries. This study has designed to investigate the epidemiology of colorectal cancer and the potential modifiable local risk factors in Tanzania. A cross sectional retrospective chart audit study was conducted to establish the pattern and distribution of colorectal cancer, The Food Frequency Questionnaire and the Step® survey tool were used to collect data. Descriptive statistics, Chi square tests and regression analysis were employed and augmented by data visualization to display risk variable differences. Tanzania‘s colorectal cancer incidence has increased six times in the last decade in which major towns and cities of Dar es Salaam (20.2 per 100 000), Pwani (7.2 per 100 000), Kilimanjaro (4.4 per 100 000), Arusha (4.2 per 100 000) and Morogoro (3.6 per 100 000) had the highest percentage. This study reported that, almost 45% of the participants were hypertensive. Two major dietary patterns, namely ―healthy‖ and ―western‖, existed among the study sample. Obesity was found in 25% of participants, whereas overweight was present in 28%; of note, the prevalence was higher in females (26.9%) than in males (23.6%) respectively. The prevalence of alcohol consumption was 21.5%, with a significantly lower rate of smoking (12.2%) noted within the study subjects. Both alcohol consumption and tobacco smoking were more common in men than women (22.7 vs. 20.6% and 24.5 vs. 3.2%, respectively). The prevalence of vigorous, moderate, and low physical activity for both sexes was 18.6%, 54.1% and 42.3%, respectively. Evidence from this study demonstrated that, lifestyle factors, such as diet, obesity, tobacco smoking, alcohol consumption, and sedentary behaviors, have a significant role in the rising trend of non communicable diseases and colorectal cancer in Tanzania. We recommend a large longitudinal study with robust methodology which can establish cause and effect relationships between specific lifestyle behaviors and the prevalence of colorectal cancer. en_US
dc.language.iso en_US en_US
dc.publisher NM-AIST en_US
dc.subject Research Subject Categories::NATURAL SCIENCES en_US
dc.title Colorectal cancer epidemiology in Tanzania: patterns in relation to dietary and lifestyle factors en_US
dc.type Thesis en_US

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