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Epidemiology of intestinal schistosomiasis and efficacy of single versus repeated dose praziquantel treatments among schoolchildren in Rorya district, Northwestern Tanzania

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dc.contributor.author Munisi, David Zadock
dc.date.accessioned 2019-06-04T09:06:57Z
dc.date.available 2019-06-04T09:06:57Z
dc.date.issued 2018-12
dc.identifier.uri http://dspace.nm-aist.ac.tz/handle/123456789/292
dc.description A Dissertation Submitted in Partial Fulfilment of the Requirements for the Degree of Doctor of Philosophy in Life Sciences of the Nelson Mandela African Institution of Science and Technology en_US
dc.description.abstract In Schistosoma mansoni endemic areas, administering repeated treatments may increase praziquantel cure rate (CR) and egg reduction rate (ERR), thereby improving morbidity reduction and hastening achievement of transmission control in these areas. This was a longitudinal study which investigated the efficacy of single versus repeated praziquantel treatments of S.mansoni infections and its impact on undernutrition and anaemia. Stool samples were collected from 513 schoolchildren and examined for S.mansoni infections using the Kato-Katz method. Questionnaires were used to collect sociodemographic data, risk factors, knowledge, attitude and practices on schistosomiasis. Nutritional status was determined by anthropometry. Blood samples were collected and examined for malaria parasites and haemoglobin levels using the Giemsa stain and HaemoCue methods, respectively. The prevalence of S.mansoni, malaria, stunting, wasting and anaemia were 84.01%, 9.16%, 38.21%, 14.42% and 29.43%, respectively. The geometric mean (GM) egg per gram of stool for S.mansoni was 167.13 (95%CI: 147.19–189.79) eggs per gram of stool. Village of residence, parent’s level of education, toilet use and treatment history were predictors of S.mansoni infection. A total of 431 S.mansoni infected schoolchildren were randomized to either receive a single or repeated 40mg/kg dose of praziquantel. At 8 weeks post baseline treatment, CR was higher among those on repeated dose (93.10%) than those on a single dose (68.68%, p<0.001). Likewise, ERR was higher among those on repeated dose (97.54%) than on a single dose (87.27%, p=0.0062). GM epg was lower among those on repeated dose (1.30 epg) than those on single dose (3.18 epg, p=0.036). At eight months post baseline treatment, the rate of re-infection was about 83% and 77% among those on repeated and single treatments, respectively. No significant difference was observed in the prevalence of stunting between the two treatment regimens (p>0.05), with significant increase in mean haemoglobin (p<0.05) but without significant difference between treatments (p>0.05). Majority (93%) of participants mentioned using lake water for domestic chores. Although toilet ownership was high (84.61%), regular toilet use was low (55.31%). To be of sustained benefit, repeated dose praziquantel treatments should be coupled with other control measures that aim at reducing the rate of re-infection and environmental contamination. en_US
dc.language.iso en_US en_US
dc.publisher NM-AIST en_US
dc.subject Research Subject Categories::NATURAL SCIENCES en_US
dc.title Epidemiology of intestinal schistosomiasis and efficacy of single versus repeated dose praziquantel treatments among schoolchildren in Rorya district, Northwestern Tanzania en_US
dc.type Thesis en_US


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